17100-67-3

Basic information

• Product Name: 2H-Pyran, 2-[(3-bromophenyl)methoxy]tetrahydro-
• CAS NO: 17100-67-3
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• Mol File: 17100-67-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, 2-[(3-bromophenyl)methoxy]tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, 2-[(3-bromophenyl)methoxy]tetrahydro-(17100-67-3)
• EPA Substance Registry System: 2H-Pyran, 2-[(3-bromophenyl)methoxy]tetrahydro-(17100-67-3)

Safety Data

• Hazardous Substances Data: 17100-67-3(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 15852-73-0 (3-Bromophenyl)methanol 
• 6399-81-1 triphenylphosphine hydrobromide 

Downstream Products

• 3132-99-8 m-bromobenzoic aldehyde 
• 170587-38-9 (2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsiloxy-2-[α-hydroxy-3-(tetrahydropyranyloxymethyl)benzyl]pyrrolidine 
• 1028269-03-5 2-{2-[2-(3-Benzyl-benzyl)-benzyl]-benzyloxy}-tetrahydro-pyran 
• 1026185-40-9 2-[2-(3-Benzyl-benzyl)-benzyloxy]-tetrahydro-pyran 
• 148320-05-2 2-<2-(3-Benzylbenzyl)benzyl>benzyl alcohol 
• 148320-04-1 2-(3-Benzylbenzyl)benzyl bromide 
• 148320-03-0 2-(3-Benzylbenzyl)benzyl alcohol 
• 69410-45-3 3-benzyl-1-bromomethylbenzene 
• 35714-19-3 3-Benzylbenzyl alcohol 
• 162472-06-2 7-(3-Hydroxymethyl-phenyl)-naphthalene-2-carboxylic acid methyl ester 
• 144801-69-4 7-[3-((1R,3S,5S)-3-Hydroxy-8-oxa-bicyclo[3.2.1]oct-6-en-3-yl)-benzyloxy]-4-phenyl-3H-naphtho[2,3-c]furan-1-one 
• 144801-71-8 7-[3-((1S,3R,5R)-3-Hydroxy-8-oxa-bicyclo[3.2.1]oct-3-yl)-benzyloxy]-4-phenyl-3H-naphtho[2,3-c]furan-1-one 
• 144801-22-9 7-[3-((2S,4S,6R)-4-Hydroxy-2,6-dimethyl-tetrahydro-pyran-4-yl)-benzyloxy]-4-phenyl-3H-naphtho[2,3-c]furan-1-one 
• 153607-70-6 (1R,3S,5S)-3-(3-Hydroxymethyl-phenyl)-8-oxa-bicyclo[3.2.1]oct-6-en-3-ol 

Relevant articles and documents

New Tetrahydroanthracene pyranylcyano compd. (by machine translation)

PROBLEM TO BE SOLVED: To provide a charge transport material capable of improving stability of a coating film and causing scarce side effects such as degradation of electrical properties and image deletion under high-temperature and humidity. SOLUTI

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: Structure-activity relationship study directed toward the improvement of metabolic stability

Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5- 1ipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the tetrahydropyran and the lactone rings. Early knowledge of the metabolic pathways triggered and directed a structure-activity relationship study aimed toward the improvement of metabolic stability in this series. The best modifications discovered, i.e., replacement of the lactone ring by a nitrile group, replacement of the tetrahydropyran ring by a 6,8- dioxabicyclo[3.2.1]octanyl moiety, and replacement of the pendant phenyl ring by a 3-furyl ring, were incorporated in a single molecule to produce inhibitor 9ac (L-708,780). Compound 9ac inhibits the oxidation of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid by 5-LO (IC50 = 190 nM) and the formation of leukotriene B4 in human polymorphonuclear leukocytes (IC50 = 3 nM) as well as in human whole blood (IC50 = 150 nM). The good inhibitory profile shown by naphthalenenitrile 9ac is accompanied by an improved resistance to oxidative metabolism. In addition, 9ac is orally active in the functional model of antigen-induced bronchoconstriction in allergic squirrel monkeys (95% inhibition at 0.1 mg/kg).

Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Compounds having the formula I: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.