17100-70-8Relevant articles and documents
Synthesis of riccardin D derivatives as potent antimicrobial agents
Sun, Bin,Zhang, Ming,Li, Ying,Hu, Qing-wen,Zheng, Hong-bo,Chang, Wen-qiang,Lou, Hong-Xiang,Lou, Hong-xiang
, p. 3617 - 3620 (2016)
We describe the synthesis and biological evaluation of riccardin D derivatives, a novel class of antimicrobial molecules. Structural diversification of these derivatives was achieved by introducing hydroxy, methoxy, and bromine into the aromatic rings of riccardin D. The antimicrobial evaluation of these compounds was performed as in vitro assays against clinically isolated bacteria and fungi. The introduction of bromine atom into the arene B of riccardin D led to several strongly active antibacterial compounds with a MIC value ranging from 0.5 to 4 μg/mL for Staphylococcus aureus, both methicillin-sensitive and -resistant strains. Antifungal tests found compound 34 was the most potent molecule with a MIC value of 2 μg/mL against Candida albicans. This initial biological evaluation suggests that these novel molecules merit further investigation as potential antimicrobial agents.
Syntheses of macrocyclic bisbibenzyls on solid support
Speicher, Andreas,Backes, Timo,Grosse, Stefan
, p. 11692 - 11696 (2007/10/03)
We describe a route for the polymer supported total synthesis of the cyclic bisbibenzyls of the isoplagiochin type found in liverworts. TentaGel resins were used as solid support for a sequence involving Suzuki, Wittig and hydrogenation protocols. The pol
