171011-48-6 Usage
Description
(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene is a complex organic compound with a chiral center and a unique molecular structure. It is composed of eight carbon atoms, twelve hydrogen atoms, and one silicon atom, featuring a fused ring system and several functional groups, including a silyl-protected hydroxyl group. (1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene is valuable in the field of synthetic organic chemistry for its role in creating diverse molecular structures.
Uses
Used in Organic Synthesis:
(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene is used as a reagent in organic synthesis for the construction of complex natural products and pharmaceuticals. Its chiral center and functional groups make it a versatile building block for creating stereochemically complex molecules.
Used in Protecting Groups for Alcohols:
In the field of organic synthesis, the dimethylsilyloxy group in this compound serves as a protecting group for alcohols, allowing selective manipulation of specific functional groups. This selective protection is crucial for the synthesis of complex organic molecules with precise stereochemistry.
Used in Pharmaceutical Industry:
(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene is used as a key intermediate in the synthesis of pharmaceuticals, particularly for the development of new drugs with complex molecular structures. Its unique properties and functional groups contribute to the design and synthesis of innovative therapeutic agents.
Used in Natural Product Synthesis:
(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-1-[(R)-2-hydroxy-1-methylethyl]-7a-methyl-1H-indene is also used in the synthesis of complex natural products, where its chiral center and functional groups play a crucial role in replicating the intricate structures found in nature. Its application in this field aids in the development of new bioactive compounds with potential applications in medicine and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 171011-48-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,0,1 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 171011-48:
(8*1)+(7*7)+(6*1)+(5*0)+(4*1)+(3*1)+(2*4)+(1*8)=86
86 % 10 = 6
So 171011-48-6 is a valid CAS Registry Number.
171011-48-6Relevant articles and documents
Efficient synthesis and biological evaluation of all A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and its 20-epimer
Fujishima, Toshie,Konno, Katsuhiro,Nakagawa, Kimie,Kurobe, Mayuko,Okano, Toshio,Takayama, Hiroaki
, p. 123 - 134 (2000)
An improved synthesis of the diastereomers of 1α,25-dihydroxyvitamin D3 (1) was accomplished utilizing our practical route to the A-ring synthon. We applied this procedure to synthesize for the first time all possible A- ring diastereomers of 20-epi-1α,25-dihydroxyvitamin D3 (2). Ten-step conversion of 1-(4-methoxyphenoxy)but-3-ene (6), including enantiomeric introduction of the C-3 hydroxyl group to the olefin by the Sharpless asymmetric dihydroxylation, provided all four possible stereoisomers of A- ring enynes (3), i.e., (3R,5R)-, (3R,5S)-, (3S,5R)- and (3S,5S)-bis[(tert- butyldimethylsilyl)oxy]oct-1-en-7-yne, in good overall yield. Palladium- catalyzed cross-coupling of the A-ring synthon with the 20-epi CD-ring portion (5), (E)-(20S)-de-A,B-8-(bromomethylene)cholestan-25-ol, followed by deprotection, afforded the requisite diastereomers of 20-epi-1α,25- dihydroxyvitamin D3 (2). The biological profiles of the synthesized stereoisomers were assessed in terms of affinities for vitamin D receptor (VDR) and vitamin D binding protein (DBP), HL-60 cell differentiation- inducing activity and in vivo calcium-regulating potency in comparison with the natural hormone. (C) 2000 Elsevier Science Ltd.
Synthesis of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]
Yoshino, Madoka,Eto, Kohei,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi,Ono, Yoshiyuki,Saito, Hitoshi,Kubodera, Noboru
experimental part, p. 381 - 394 (2010/09/05)
A convergent synthesis of biologically interesting 20-epi-eldecalcitol which possesses an inverted C-21 methyl substituent at the 20-position of the side chain of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (eldecalcitol) is described.
2-METHYLENE-19,26,27-TRINOR-(20S)-1α-ALPHA-HYDROXYVITAMIN D3 AND ITS USES
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Page/Page column 11, (2010/11/08)
This invention discloses 2-methylene-19,26,27-trinor-(20S)-vitamin D analogs, and specifically 2-methylene-19,26,27-trinor-(20S)-lα-hydroxyvitamirt D3 and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the
