171020-52-3

Basic information

• Product Name: 2-Bromo-N-(4-methoxy-benzyl)-N-((E)-styryl)-butyramide
• CAS NO: 171020-52-3
• Molecular Weight: 388.304
• Mol File: 171020-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Bromo-N-(4-methoxy-benzyl)-N-((E)-styryl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-(4-methoxy-benzyl)-N-((E)-styryl)-butyramide(171020-52-3)
• EPA Substance Registry System: 2-Bromo-N-(4-methoxy-benzyl)-N-((E)-styryl)-butyramide(171020-52-3)

Safety Data

• Hazardous Substances Data: 171020-52-3(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 122-78-1 phenylacetaldehyde 
• 26074-52-2 2-bromo-butyryl bromide 

Relevant articles and documents

Synthesis of 4-oxo-2-azetidineacetic acids by means of radical cyclization of N-vinylic α-bromo amides

Bu2SnH-mediated radical cyclization of α-bromo amide 8, bearing phenyl and phenylthio substituents at the terminus of the N-vinylic bond, proceeded in a 4-exo-trig manner to give β-lactam 9. Ruthenium tetroxide oxidation of the phenyl group incorporated into the product 9 provided a new synthesis of 4-oxo-2-azetidineacetic acid 13, a useful intermediate for (±)-PS-5. Chiral 4-oxo-2-azetidineacetic acids 23 and 36, key intermediates for the synthesis of (+)-PS-5 and (+)-thienamycin, respectively, were also obtained through the asymmetric radical cyclization of N-vinylic α-bromo amides having chiral auxillaries at the side-chain.