17103-52-5Relevant articles and documents
Facile and convenient synthesis of new isoxazolo[5,4b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives with potential anticancer activity
El-Mekabaty, Ahmed,Ibrahim, Mona E.
, p. 901 - 915 (2020/09/09)
The readily available 3-methylisoxazol-5-amine (1) has been used as a key intermediate for the synthesis of isoxazolo[5,4-b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]azepine-4,7-dione and isoxazole derivatives via its reactions with some chemical reagents. Sixteen compounds were designed to study their cytotoxic properties against three human cell lines: colorectal carcinoma (HCT-116), prostate cancer (PC3) and normal lung fibroblast (WI-38), using the MTT colorimetric assay. 5-Fluorouracil, a well-known anticancer drug, was used for comparison. Among the tested candidates, pyrrolo[3,2-d]isoxazole 5 and isoxazole derivatives 11-14 showed the highest activity against the tested cancer cell lines with good selectivity by their lower toxicity against normal cells.