171092-38-9

Basic information

• Product Name: Ethanone, 1-[3-(3-pyridinyl)phenyl]-
• CAS NO: 171092-38-9
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Mol File: 171092-38-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[3-(3-pyridinyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[3-(3-pyridinyl)phenyl]-(171092-38-9)
• EPA Substance Registry System: Ethanone, 1-[3-(3-pyridinyl)phenyl]-(171092-38-9)

Safety Data

• Hazardous Substances Data: 171092-38-9(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[3-(3-pyridinyl)phenyl]-, also known as 3-(3-pyridinyl) phenylacetophenone, is a chemical compound with a molecular formula C17H13NO that belongs to the ketone group. It is a synthetic compound used in various research and industrial applications, primarily as a building block for the synthesis of pharmaceuticals and agrochemicals. Ethanone, 1-[3-(3-pyridinyl)phenyl]- has been studied for its potential pharmacological properties, including anti-inflammatory, antitumor, and antifungal activities. Its aromatic structure with both pyridine and phenyl components suggests potential applications in drug design and discovery. The compound may also find uses in organic synthesis and as a reagent in laboratory experiments.

Upstream product

• 1692-25-7 3-pyridylboronic acid 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 626-60-8 3-Chloropyridine 
• 224311-51-7 johnphos 
• 626-55-1 3-Bromopyridine 

Downstream Products

• 1436712-56-9 1-ethyl-2-methyl-2-(3-(pyridin-3-yl)phenyl)-2,5-dihydro-1H-imidazol-4-amine 

Relevant articles and documents

Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity

By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. Since synthesis feasibility had low priority in the design of the cores, an extensive synthesis effort was needed to make the relevant compounds. Syntheses of these compounds are reported, together with physicochemical properties and structure-activity relationships based on in vitro data. Four crystal structures of diverse amidines binding in the active site are deposited and discussed. Inhibitors of BACE-1 with 3 μM to 32 nM potencies in cells are shown, together with data on in vivo brain exposure levels for four compounds. The results presented show the importance of the core structure for the profile of the final compounds.

Efficient diphosphane-based catalyst for the palladium-catalyzed suzuki cross-coupling reaction of 3-pyridylboronic acids

A highly active catalyst system derived from PdCl2 and 2,2',6,6'- tetramethoxy-4,4'-bis(diphenylphosphanyl)-3,3'-bi- pyridine (P-Phos) has been developed for the Suzuki cross- coupling reaction of pyridylboronic acid with a variety of aryl halides in good to excellent yields, even in the presence of hindered and functional groups. In addition, P-Phos also exhibited high activity in the palladium-catalyzed Suzuki reaction of 2,6-dimethoxypyridylboronic acid in excellent yields with a fast rate. The steric and electronic effects of the P- Phos-palladium complex to this cross-coupling reaction were also discussed.

Ligands for metals and improved metal-catalyzed processes based thereon

One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.