171119-05-4

Basic information

• Product Name: 2-Oxo-2-(4-methoxyphenyl)ethyl formate
• Synonyms: 2-Oxo-2-(4-methoxyphenyl)ethyl formate
• CAS NO: 171119-05-4
• Molecular Weight: 194.187
• Mol File: 171119-05-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Oxo-2-(4-methoxyphenyl)ethyl formate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-2-(4-methoxyphenyl)ethyl formate(171119-05-4)
• EPA Substance Registry System: 2-Oxo-2-(4-methoxyphenyl)ethyl formate(171119-05-4)

Safety Data

• Hazardous Substances Data: 171119-05-4(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 1076-95-5 p-methoxyphenylglyoxal 
• 122-52-1 triethyl phosphite 
• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 80336-72-7 2-iodo-1-(4-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 146335-19-5 1-(4-methoxyphenyl)ethenyl methyl carbonate 

Downstream Products

• 4136-21-4 p-methoxybenzoylmethanol 

Relevant articles and documents

Fast-Synthesis of α-Phosphonyloxy Ketones as Drug Scaffolds in a Capillary Microreactor

A simple, room temperature approach for the fast single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, has been developed which involves highly reactive species i.e., 1,2-dicarbonyls that readily react with trialkyl phosphites and formic acids in batch as well as in continuous-flow with the flow rate of 3 ml/min (tR = ～4 s). The present approach reduced the synthesis time from hours to minutes in batch, which was further lowered to a few seconds precisely controlled by single capillary microfluidics. A wide range of 1,2-dicarbonyl derivatives were smoothly transformed to their corresponding α-phosphonyloxy ketones in moderate to good yields (50–82 %) under optimized flow-reaction conditions. Further, the α-phosphonyloxy ketones produced can be utilized in batch process to form benzoin, oxazole core, and α,α′-diarylated carbonyl compounds in 82 %, 50 %, and 54 % yields, respectively, which are alternative key precursors/scaffolds of natural products and active pharmaceutical ingredients (APIs).

A sustainable byproduct catalyzed domino strategy: Facile synthesis of α-formyloxy and acetoxy ketones via iodination/nucleophilic substitution/hydrolyzation/oxidation sequences

The sustainable byproduct catalyzed domino strategy has been performed for the facile synthesis of α-formyloxy and acetoxy ketones via iodination/nucleophilic substitution/hydrolyzation/oxidation sequences from simple and readily available aromatic ketone

Synthesis of α-acetoxy and formyloxy ketones by thallium(III) promoted α-oxidation

Treatment of ketones with thallium(III) triflate in amide solvents at 60°C for 30 min followed by addition of small amounts of H2O cleanly provided the corresponding α-acyloxy ketones.