171259-81-7 Usage
Description
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide, also known as A611500, is a potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. It is a white to off-white solid and does not interfere with binding sites for kainic acid in vitro. The neuronal excitation induced by A611500 is not significantly affected by NMDA antagonists.
Uses
1. Used in Pharmaceutical Industry:
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide is used as a pharmaceutical compound for its agonistic properties on L-glutamic Acid receptors. It can be utilized in the development of drugs targeting neurological disorders and conditions related to neurotransmission.
2. Used in Research and Development:
A611500 is used as a research tool in the field of neuroscience to study the effects of L-glutamic Acid on neuronal excitation and neurotransmission. It can help researchers understand the underlying mechanisms of various neurological conditions and develop targeted therapies.
3. Used in Drug Discovery:
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide can be employed in drug discovery processes to identify potential therapeutic agents that modulate L-glutamic Acid receptors. This can lead to the development of new drugs for treating neurological disorders.
4. Used in Neurotransmitter Studies:
A611500 is used in neurotransmitter studies to investigate the role of L-glutamic Acid in neuronal communication and its involvement in various physiological processes. This can provide insights into the development of drugs that target specific neurotransmitter systems.
Biochem/physiol Actions
(±)-AMPA is a potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 171259-81-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,2,5 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 171259-81:
(8*1)+(7*7)+(6*1)+(5*2)+(4*5)+(3*9)+(2*8)+(1*1)=137
137 % 10 = 7
So 171259-81-7 is a valid CAS Registry Number.
171259-81-7Relevant articles and documents
An expedient synthesis of (±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide via a 3-bromoisoxazole intermediate
Hanson, Robert N.,Mohamed, Fand A.
, p. 345 - 348 (2007/10/03)
The excitatory, amino acid ± 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide was prepared in gram quantities in a 3.3% overall yield from methylbut 2-ynoate. The key step was the facile preparation of methyl 3-bromo-5-methylisoxazole-4-carboxylate.