171284-22-3

Basic information

• Product Name: 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite
• CAS NO: 171284-22-3
• Molecular Weight: 438.591
• Mol File: 171284-22-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite(171284-22-3)
• EPA Substance Registry System: 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite(171284-22-3)

Safety Data

• Hazardous Substances Data: 171284-22-3(Hazardous Substances Data)

Upstream product

• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 59012-91-8 2,2-dimethyl-propionic acid 4-hydroxymethyl-phenyl ester 

Relevant articles and documents

Synthesis, bioactivation and anti-HIV activity of 4-acyloxybenzyl bis(nucleosid-5'-yl) phosphates

4-Acyloxybenzyl bis(nucleosid-5'-yl) phosphates 7a-c and 9a-c were prepared as potential prodrugs of the anti-HIV nucleosides 3'-azido-3'- deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI) or their 5'- monophosphates. The anti-HIV activities of these triesters were determined in two T-cell lines. In a C8166 cell line they displayed activities comparable to and in some cases superior to AZT, but they also exhibited an increase in cytotoxicity. In a thymidine kinase deficient JM T-cell line the activity was reduced but was still superior to AZT. In the presence of porcine liver carboxyesterase (PLCE), triester 7b biodegrades to the diester 10 which, with phosphodiesterase, gives initially AZT monophosphate 3 and AZT.