1713-85-5Relevant articles and documents
Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides
Delforge, Arnaud,Georgiou, Irene,Kremer, Adrian,Wouters, Johan,Bonifazi, Davide
, p. 4844 - 4847 (2016)
A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.
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Koelsch
, p. 1105 (1930)
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Synthesis of an Alkene-Containing Copolylactide and Its Facile Modification by the Addition of Thiols
Kalelkar, Pranav P.,Alas, Guillermo R.,Collard, David M.
, p. 2609 - 2617 (2016)
The ring-opening copolymerization of 3,6-bis(chloromethyl)-1,4-dioxane-2,5-dione and l-lactide affords a chloro-substituted polylactide copolymer (chloro-PL). Base-promoted dehydrochlorination of chloro-PL provides a copolymer (ene-PL) that contains electrophilic α,β-unsaturated ester units. The copolymer undergoes conjugate addition with a variety of thiols in solution under mildly basic conditions and also in the presence of AIBN. Reaction on the surface of films of the unsaturated copolyester is demonstrated by the addition of a thiol-substituted fluorescent dye.
3,6-dichloromethyl glycolide and preparation method and application thereof
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Paragraph 0012-0014, (2017/04/27)
The invention provides a monomer material 3,6-dichloromethyl glycolide which can be used for synthesizing biodegradable polyester. The 3,6-dichloromethyl glycolide is white crystals, the molecular formula of the 3,6-dichloromethyl glycolide is C6H6Cl2O4, and the molecular weight of the 3,6-dichloromethyl glycolide is 212. The synthetic route of the 3,6-dichloromethyl glycolide is that epoxy chloropropane or 3-chloro-1,2-propylene glycol is subjected to oxidation reaction and ring-closure reaction to prepare novel six-membered cyclic ester monomer, namely the 3,6-dichloromethyl glycolide. The 3,6-dichloromethyl glycolide can be used for synthesizing the biodegradable functional polyester; since a side chain of the 3,6-dichloromethyl glycolide contains methyl chloride, the 3,6-dichloromethyl glycolide can be used for preparing polyester, of which a side chain contains methyl chloride; and the 3,6-dichloromethyl glycolide can further react with a series of hydroxy and amino compounds to realize modification of physical, chemical and biological properties of the polyester. The 3,6-dichloromethyl glycolide has the advantages that the raw material is cheap and has wide sources, a preparation method is simple and the application value is high.
