171367-22-9 Usage
Description
Metoclopramide N-Oxide, also known as Metoclopramide EP Impurity G, is a new metabolite derived from Metoclopramide (M338685). It is a chemical compound that has been identified as a result of the metabolism of the parent drug, Metoclopramide.
Uses
Used in Pharmaceutical Industry:
Metoclopramide N-Oxide is used as a metabolite for understanding the metabolic pathways and pharmacokinetics of Metoclopramide. This knowledge can be crucial in optimizing the drug's efficacy, safety, and dosing regimens.
Used in Research and Development:
Metoclopramide N-Oxide serves as a valuable compound in the research and development of new drugs and therapies. It can be used to study the mechanisms of action, potential side effects, and interactions with other drugs or biological systems.
Used in Quality Control:
In the pharmaceutical quality control process, Metoclopramide N-Oxide can be used as a reference impurity to ensure the purity and quality of Metoclopramide drug products. This helps in maintaining the safety and efficacy of the drug for patients.
Used in Drug Metabolism Studies:
Metoclopramide N-Oxide is used as a subject in drug metabolism studies to investigate how the body processes and eliminates Metoclopramide. This information can be vital for predicting drug interactions, understanding the drug's effects on different populations, and developing personalized treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 171367-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,3,6 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 171367-22:
(8*1)+(7*7)+(6*1)+(5*3)+(4*6)+(3*7)+(2*2)+(1*2)=129
129 % 10 = 9
So 171367-22-9 is a valid CAS Registry Number.
171367-22-9Relevant articles and documents
Identification and full characterization of a new metabolite of metoclopramide
Maurich, V.,Amici, M. De,Micheli, C. De,Rossato, P.
, p. 757 - 762 (2007/10/03)
The metabolism of metoclopramide 1 has been reinvestigated by HPLC coupled with mass spectrometry.The urine of healthy volunteers showed the presence of a new metabolite 2 derived from the enzymatic oxidation of the primary aromatic amino group of 1 to the hydroxylamino moiety.The structure of the new metabolite was ascertained by its fragmentation pattern in the mass spectrometer and unambiguously secured by an independent synthesis.In addition, the tertiary amine group of 1 was selectively oxidized to the corresponding N-oxide.This compound and its ring oxidation metabolites were not detected in the urine of the tested volunteers. metoclopramide metabolism / metabolite / arylhydroxylamino derivative / metoclopramide N-oxide
