171414-17-8

Basic information

• Product Name: N-[(4-methoxyphenyl)methyl]-4-nitro-benzenesulfonamide
• Synonyms: N-[(4-methoxyphenyl)methyl]-4-nitro-benzenesulfonamide
• CAS NO: 171414-17-8
• Molecular Weight: 322.342
• Mol File: 171414-17-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-[(4-methoxyphenyl)methyl]-4-nitro-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-methoxyphenyl)methyl]-4-nitro-benzenesulfonamide(171414-17-8)
• EPA Substance Registry System: N-[(4-methoxyphenyl)methyl]-4-nitro-benzenesulfonamide(171414-17-8)

Safety Data

• Hazardous Substances Data: 171414-17-8(Hazardous Substances Data)

Upstream product

• 6325-93-5 p-nitrobenzenesulfonamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 840529-62-6 N-p-nosyl-4-methoxy-phenylmethylimine 
• 104-93-8 p-methylanizole 
• 18922-62-8 N-(4-nitro-benzenesulfonyl)-S,S-diphenylsulfilimine 
• 2393-23-9 4-methoxy-benzylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 128886-84-0 p-Chlorophenyl p-nitrobenzenesulphonate 
• 321578-69-2 4-tolyl 4-nitrobenzenesulfonate 
• 30362-87-9 p-Nitrophenyl p-nitrobenzenesulphonate 
• 32337-46-5 Phenyl p-nitrobenzenesulphonate 

Downstream Products

• 55539-39-4 p-methoxybenzylphenylsulfone 
• 1579269-14-9 N-(4-methoxybenzyl)-4-nitro-N-(3-oxopropyl)benzenesulfonamide 
• 1579269-20-7 5-(4-methoxyphenyl)-2-((4-nitrophenyl)sulfonyl)-6-tosyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 
• 1579269-17-2 N-(3-hydroxy-3-(1-tosyl-1H-indol-2-yl)propyl)-N-(4-methoxybenzyl)-4-nitrobenzenesulfonamide 
• 171414-22-5 N-Benzyl-N-(4-methoxy-benzyl)-4-nitro-benzenesulfonamide 

Relevant articles and documents

Visible-light, iodine-promoted formation of n-sulfonyl imines and n-alkylsulfonamides from aldehydes and hypervalent iodine reagents

Alternative synthetic methodology for the direct installation of sulfonamide functionality is a highly desirable goal within the domain of drug discovery and development. The formation of synthetically valuable N-sulfonyl imines from a range of aldehydes,

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HTS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial β-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure-activity relationships of these compounds were explored.

Catalyst-free alkylation of sulfinic acids with sulfonamides via sp 3 C-N bond cleavage at room temperature

An unprecedented catalyst-free alkylation of sulfinic acids with sulfonamides has been developed via sp3 C-N bond cleavage at room temperature. In the absence of external catalysts and additives, a wide variety of N-benzylic and N-allylic sulfonamides couple with sulfinic acids to give structurally diversified sulfones in moderate to excellent yields. Furthermore, the reaction of N-(2-acyl)allylic sulfonamides with sulfinic acids provides a convenient access to trisubstituted allyl sulfones with exclusive Z selectivity.