17147-42-1Relevant articles and documents
Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study
Qiu, Rongmao,Luo, Guoshun,Li, Xinyu,Zheng, Fan,Li, Haolin,Zhang, Jin,You, Qidong,Xiang, Hua
supporting information, p. 2879 - 2884 (2018/07/25)
In continuation of our drug discovery program on hyperlipidemia, a series of novel isoxazole-chenodeoxycholic acid hybrids were designed, synthesized and evaluated for their lipid-lowering effects. Preliminary screening of all the synthesized compounds was done by using a 3T3-L1 adipocyte model, in which the most active compound 16b could significantly reduce the lipid accumulation up to 30.5% at a nontoxic concentration 10 μM. Further mechanism studies revealed that 16b blocked lipid accumulation via activating FXR-SHP signaling pathway, efficiently down-regulated the expression of key lipogenesis regulator SREBP-1c.
Synthesis of five-membered heterocycles containing a nitrogen-oxygen bond via O-acylation of aliphatic nitro compounds
Harada,Kaji,Zen
, p. 3296 - 3303 (2007/10/02)
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ANTIANDROGENIC N-(3,5-DILOWER ALKYL-4-HETEROCYCLIC)METHYL)PHTHALIMIDES
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, (2013/12/16)
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