171511-22-1Relevant articles and documents
A Facile Synthesis of 5H-1-Thia-3,5,6,8-tetraazaacenaphthylenes
Tumkevicius, Sigitas
, p. 1703 - 1706 (2007/10/02)
Ethyl 5-substituted 7-(methylthio)-5H-1-thia-3,5,6,8-tetraazaacenaphthylene-2-carboxylates (5a-f) representing a new heterocyclic system were prepared by acid-catalyzed cyclocondensation of ethyl 5-amino-4-(substituted amino)-2-(methylthio)thienopyrimidine-6-carboxylates (3a-f) with triethyl orthoformate.Compounds 3 were obtained by aminolysis of 4,6-dichloro-2-(methylthio)pyrimidine-5-carbonitrile (1) affording 2 followed by base-promoted cyclization with sodium ethyl thioglycolate. - Keywords: Thienopyrimidines, 4,5-diamino- / Triethyl orthoformate / Cyclocondensation / 5H-1-Thia-3,5,6,8-tetraazaacenaphthylenes