1716-77-4

Basic information

• Product Name: 3-Phenyl-3-hydroxy-3-(trifluoromethyl)propionic acid
• Synonyms: 3-Phenyl-3-hydroxy-3-(trifluoromethyl)propionic acid
• CAS NO: 1716-77-4
• Molecular Weight: 234.175
• Mol File: 1716-77-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Phenyl-3-hydroxy-3-(trifluoromethyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-3-hydroxy-3-(trifluoromethyl)propionic acid(1716-77-4)
• EPA Substance Registry System: 3-Phenyl-3-hydroxy-3-(trifluoromethyl)propionic acid(1716-77-4)

Safety Data

• Hazardous Substances Data: 1716-77-4(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 63741-28-6 R-β-hydroxy β-phenyl β-trifluoro-propanoate de t-butyle 
• 7732-18-5 water 
• 63741-25-3 α-(p-tolylsulfinyl) β-hydroxy β-phenyl β-trifluoromethyl propanoate de t-butyle 
• 153816-97-8 3-phenyl-3-trifluoromethyl-3-propanolide 
• 64-19-7 acetic acid 

Downstream Products

• 153816-97-8 3-phenyl-3-trifluoromethyl-3-propanolide 

Relevant articles and documents

Boron-catalyzed carboxylic acid-selective aldol reaction with trifluoromethyl ketones

A catalytic carboxylic acid-selective aldol reaction with trifluoromethyl ketones was developed. Reversible and selective covalent bond formation between a boron catalyst and a carboxylic acid is key to realizing the unprecedented catalytic aldol reaction of simple carboxylic acids. The reaction proceeded chemoselectively at the α-position of carboxylic acid even in the presence of ketone, ester, or amide functional groups in the donor substrates. The chemoselectivity is beneficial for late-stage derivatizations of biologically relevant compounds, as demonstrated by the conversion of indomethacin and triacetylcholic acid.

Piperidine derivatives with PAF antagonist activity

Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their prepara

Synthesis and Structure-Activity Relationships of 1-Acyl-4-(2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF Antagonists

A second generation of (cyanomethyl)piperazines, 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines, with increased oral activity was prepared and evaluated in vitro in PAF-induced platelet aggregation assay (PAG) and in vivo in a PAF-induced hypotension test in normotensive rats (HYP).Oral activity was ascertained through a PAF-induced mortality test in mice (MOR).Attachment of a methyl group at position 2 of our earlier pyridine derivatives resulted in an improvement of 1 order of magnitude or greater in the ID50 of the oral test.Three different types of acylsubstituents of similar potency emerge from this work: N-(diphenylmethylamino)acetyl, 3-substituted 3-hydroxy-3-phenylpropionyl, and N-substituted 3-amino-3-phenylpropionyl groups.The most interesting compounds, 26 (UR-12460, PAG IC50 = 0.040 μM, HYP, ID50 = 0.021 mg/kg iv, MOR, ID50 = 0.30 mg/kg po) and 58 (UR-12519, PAG IC50 = 0.041 μM, HYP, ID50 = 0.015 mg/kg iv, MOR, ID50 = 0.044 mg/kg po), compare favorably with WEB-2086.Compounds 26 and 58 were also tested in active anaphylactic shock (AAS) and endotoxin-induced mortality (EIM) tests.On the basis of these data, compounds 26 and 58 have been selected for further pharmacological development.