17179-18-9Relevant articles and documents
Iron-Catalyzed Alkylation of Nitriles with Alcohols
Ma, Wei,Cui, Suiya,Sun, Huamin,Tang, Weijun,Xue, Dong,Li, Chaoqun,Fan, Juan,Xiao, Jianliang,Wang, Chao
supporting information, p. 13118 - 13123 (2018/09/11)
A general, efficient iron-catalyzed α-alkylation of nitriles with primary alcohols through a hydrogen-borrowing pathway has been developed, allowing a wide variety of alkylated nitriles to be readily accessible. Detailed mechanistic studies suggest that the reaction proceeds via an olefin intermediate with the turnover rate limited by the hydrogenation of the olefin with an iron hydride. Apart from participating in the alkylation, the nitrile is found to play an important role in promoting the formation of and stabilizing the active catalytic species.
Nickel-catalyzed decyanation of inert carbon-cyano bonds
Patra, Tuhin,Agasti, Soumitra,Akanksha,Maiti, Debabrata
supporting information, p. 69 - 71 (2013/02/21)
Nickel catalyzed decyanation of aryl and aliphatic cyanides with hydrosilane as the hydride source has been developed. This method is easy to handle, scalable and can be carried out without a glove box. The method has been applied in the cyanide directed functionalization reaction and α-substitution of benzyl cyanide.
