171850-29-6

Basic information

• Product Name: 5,7-DICHLOROQUINOLIN-4-OL
• Synonyms: 5,7-DICHLOROQUINOLIN-4-OL;5,7-Dichloro-4-hydroxyquinoline
• CAS NO: 171850-29-6
• Molecular Formula: C₉H₅Cl₂NO
• Molecular Weight: 214.0481
• EINECS: 427-420-0
• Product Categories: Quinoline
• Mol File: 171850-29-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 340.2 °C at 760 mmHg
• Flash Point: 159.5 °C
• Appearance: /
• Density: 1.466 g/cm³
• Vapor Pressure: 8.74E-05mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• PKA: 3.09±0.40(Predicted)
• CAS DataBase Reference: 5,7-DICHLOROQUINOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DICHLOROQUINOLIN-4-OL(171850-29-6)
• EPA Substance Registry System: 5,7-DICHLOROQUINOLIN-4-OL(171850-29-6)

Safety Data

• Hazard Codes: Irritant:
• Hazardous Substances Data: 171850-29-6(Hazardous Substances Data)

Usage

Description

5,7-DICHLOROQUINOLIN-4-OL, also known as 5,7-Dichloro-4-hydroxyquinoline, is an organic compound that serves as an intermediate in the synthesis of various chemical compounds. It is characterized by its quinoline structure with two chlorine atoms at the 5th and 7th positions and a hydroxyl group at the 4th position. This unique structure endows it with specific properties that make it useful in various applications.

Uses

Used in Agricultural Industry:
5,7-DICHLOROQUINOLIN-4-OL is used as an intermediate in the synthesis of Quinoxyfen-d4 (Q765502), an isotope-labelled version of Quinoxyfen. Quinoxyfen acts as an agricultural fungicide, helping to protect crops from fungal infections and diseases. The use of 5,7-DICHLOROQUINOLIN-4-OL in this context is crucial for the development of effective and targeted fungicides that can improve crop yield and quality.

InChI:InChI=1/C9H5Cl2NO/c10-5-3-6(11)9-7(4-5)12-2-1-8(9)13/h1-4H,(H,12,13)

Upstream product

• 131123-76-7 5,7-dichlorokynurenic acid 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 626-43-7 3,5-Dichloroaniline 
• 157848-08-3 5,7-dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester 
• 158591-48-1 4-hydroxy-5,7-dichloroquinoline-3-carboxylic acid 
• 93514-82-0 ethyl 4-hydroxy-5,7-dichloroquinoline-3-carboxylate 
• 33149-04-1 β-(3,5-dichloroanilino)propionitrile 

Downstream Products

• 23834-01-7 4,5,7-trichloroquinoline 
• 203261-25-0 4-bromo-5,7-dichloroquinoline 
• 5437-27-4 N⁴,N⁴-diethyl-N¹-(5,7-dichloro-[4]quinolyl)-1-methyl-butanediyldiamine 
• 124495-18-7 5,7-dichloro-4-(4-fluorophenoxy)quinoline 

Relevant articles and documents

A phenoxy quinoline and its synthetic method (by machine translation)

The invention discloses a phenoxy quinoline and its synthetic method, the phenoxy quinoline comprises the following raw materials: water, ethyl acrylate, zinc chloride, glacial acetic acid, 3, 5 - dichloroaniline, ethanol, sodium hydroxide, toluene, poly phosphoric acid, n-octane, Pd/C catalyst, dichloroethane, phosphorus oxychloride, para-phenol and N, N - dimethyl formamide. This invention resulting of phenoxy quinoline content of greater than 98.0%, yield is 50% or more, the production cost is low, its synthetic combinations not needed in the process by the hydrolysis, such as high-temperature decarboxylation process, less operation step, mild reaction conditions, low equipment requirements, production of good product quality, is suitable for large-scale production enterprises. (by machine translation)

Development of an efficient process for 4,5,7-trichloroquinoline, a key intermediate for agrochemical synthesis

A short, simple, and industrially feasible process for the preparation of 4,5,7-trichloroquinoline, starting from 3,5-dichloroaniline and acrylonitrile, in essentially three steps, is discussed. This article presents the preparative process, including the

Catalytic enantioselective reissert-type reaction: Development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst

Full details of the first catalytic enantioselective Reissert-type reaction are described. Utilizing the Lewis acid-Lewis base bifunctional catalyst 5 or 6 (9 mol %), the Reissert products were obtained in 57 to 99% yield with 54 to 96% ee. Electron-rich