171856-36-3

Basic information

• Product Name: (S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide
• Synonyms: (S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide
• CAS NO: 171856-36-3
• Molecular Weight: 318.418
• Mol File: 171856-36-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide(171856-36-3)
• EPA Substance Registry System: (S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide(171856-36-3)

Safety Data

• Hazardous Substances Data: 171856-36-3(Hazardous Substances Data)

Upstream product

• 56583-58-5 N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 180046-99-5 SDZ NKT-343 
• 138449-60-2 (2S,4R)-Hyp-L-Nap-NMeBzl 
• 138449-25-9 Boc-(2S,4R)-Hyp-L-Nap-NMeBzl 

Relevant articles and documents

Modification of the potent peptide FK888 with unusual aminoacids: Effects on activity on neurokinin receptors

We report on the synthesis and the pharmacological properties of a new series of tachykinin antagonists based on the peptide N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N-m ethyl-N-(phe-nylmethyl)-3-(2-naphthyl)-L-alaninamide (FK888) modified on the (2-naphthyl)-L-alanine and the [(1-methyl-1H-indol-3-yl)carbonyl] moieties. The compounds were tested on guinea pig ileum for NK-1, rat colon for NK-2 and rat portal vein for NK-3 receptors. The two most potent peptides of this series, 1b and 2d, were selective for the NK-2 receptor (pA2 = 7.5 and 7.3, respectively).