1721-96-6

Basic information

• Product Name: Isoquinoline, 1-methyl-3-phenyl-
• CAS NO: 1721-96-6
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol File: 1721-96-6.mol
• Article Data: 36

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1-methyl-3-phenyl-(1721-96-6)
• EPA Substance Registry System: Isoquinoline, 1-methyl-3-phenyl-(1721-96-6)

Safety Data

• Hazardous Substances Data: 1721-96-6(Hazardous Substances Data)

Upstream product

• 7431-13-2 threo-2-acetamido-1,2-diphenylethan-1-ol 
• 451-40-1 phenyl benzyl ketone 
• 75-05-8 acetonitrile 
• 14447-41-7 (E)-1-bromo-1,2-diphenylethene 
• 135365-21-8 1-methyl-3-phenyl-3,4-dihydroisoquinoline 
• 2142-69-0 2-bromophenyl methyl ketone 
• 536-74-3 phenylacetylene 
• 171258-08-5 2-(phenylethynyl)acetophenone 
• 2142-70-3 2-iodoacetophenone 
• 4809-08-9 3-phenyl-isocoumarin 
• 53067-92-8 2-(2-acetylphenyl)-1-phenylethan-1-one 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 613-91-2 acetophenone oxime 
• 57957-24-1 N-(1-phenylvinyl)acetamide 

Downstream Products

• 189816-06-6 3-Phenyl-isoquinoline-1-carbaldehyde 
• 92566-89-7 3-phenyl-isoquinoline-1-carboxylic acid 
• 1202458-12-5 1-methyl-3-phenylisoquinoline-2-oxide 

Relevant articles and documents

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Cobalt-Mediated Decarboxylative/Desilylative C?H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues

A Co(II)-mediated decarboxylative/desilylative C?H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforw

Silver/Rhodium Relay Catalysis Enables C?H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds

Employing silver/rhodium relay catalysis strategy, an intramolecular electrophilic cyclization and C?H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23–88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments. (Figure presented.).

Synthesis method of 1, 3-disubstituted isoquinoline derivative

The invention discloses a synthesis method of a 1, 3-disubstituted isoquinoline derivative, which comprises the steps of adding an enamine compound, a sulfoxide ylide compound and a dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer into an organic solvent, heating under a nitrogen condition to react, and after the reaction is completed, performing post-treatment to obtain the 1, 3-disubstituted isoquinoline compound. According to the method, the 1, 3-disubstituted isoquinoline derivative is synthesized in one step through simple and easily available raw materials, the conversion efficiency is high, and the atom economy is good; and meanwhile, the method is simple to operate, high in reaction yield and wide in substrate adaptability.