172216-91-0

Basic information

• Product Name: α,α,α-trifluoro-N-phenyl-o-acetotoluidide
• Synonyms: α,α,α-trifluoro-N-phenyl-o-acetotoluidide
• CAS NO: 172216-91-0
• Molecular Weight: 279.262
• Mol File: 172216-91-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α,α,α-trifluoro-N-phenyl-o-acetotoluidide(CAS DataBase Reference)
• NIST Chemistry Reference: α,α,α-trifluoro-N-phenyl-o-acetotoluidide(172216-91-0)
• EPA Substance Registry System: α,α,α-trifluoro-N-phenyl-o-acetotoluidide(172216-91-0)

Safety Data

• Hazardous Substances Data: 172216-91-0(Hazardous Substances Data)

Upstream product

• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 103-84-4 Acetanilid 
• 108-86-1 bromobenzene 
• 172217-04-8 α,α,α-trifluoro-o-diacetotoluidide 

Downstream Products

• 14925-11-2 α,α,α-trifluoro-N-phenyl-o-toluidine 
• 23868-11-3 ethyl 2-(phenylamino)benzoate 
• 172216-94-3 ethyl pyruvate 2-<2-(trifluoromethyl)phenyl>phenylhydrazone 
• 172216-92-1 α,α,α-trifluoro-N-nitroso-N-phenyl-o-toluidine 
• 172216-93-2 1-<2-(trifluoromethyl)phenyl>-1-phenylhydrazine 

Relevant articles and documents

Antiviral Compounds

Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.

Fischer indolization of ethyl pyruvate 2-[2- (trifluoromethyl)phenyl]phenylhydrazone and new insight into the mechanism of the Goldberg reaction. (Fischer indolization and its related compounds. XXVI)

The Fischer indolization of ethyl pyruvate 2-[2- (trifluoromethyl)phenyl]phenylhydrazone (5) gave two indolic products, ethyl 7-(trifluoromethyl)-1-phenylindole-2-carboxylate (12) as a minor product and ethyl 1-[2-(trifluoromethyl)phenyl]indole-2-carboxylate (13) as a major product. This result shows that the Fischer indolization occurred on the more electron-rich phenyl group. In the Goldberg reaction to prepare 13 from ethyl indole-2-carboxylate (15) and o- (21) or m-bromo-α,α,α-trifluorotoluene (23), it was found that Goldberg reaction proceeds via a benzyne mechanism, at least in part, in a sterically crowded situation.

Synthesis of coumarin derivatives as possible antifungal and antibacterial agents

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