17230-47-6Relevant articles and documents
Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid
Hu,Meuillet,Qiao,Berggren,Powis,Kozikowski
, p. 7415 - 7418 (2007/10/03)
1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K. (C) 2000 Published by Elsevier Science Ltd.