172424-27-0

Basic information

• Product Name: Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-
• CAS NO: 172424-27-0
• Molecular Formula: C11H11F3O2
• Molecular Weight: 232.202
• Mol File: 172424-27-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-(172424-27-0)
• EPA Substance Registry System: Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-(172424-27-0)

Safety Data

• Hazardous Substances Data: 172424-27-0(Hazardous Substances Data)

Upstream product

• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 141-78-6 ethyl acetate 
• 122-79-2 Phenyl acetate 
• 876-27-7 4-chlorophenyl acetate 
• 108-22-5 Isopropenyl acetate 
• 108-05-4 vinyl acetate 

Downstream Products

• 1737-26-4 (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol 

Relevant articles and documents

PQXdpap: Helical Poly(quinoxaline-2,3-diyl)s Bearing 4-(Dipropylamino)pyridin-3-yl Pendants as Chirality-Switchable Nucleophilic Catalysts for the Kinetic Resolution of Secondary Alcohols

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-(dipropylamino)pyridin-3-yl pendants at the 5-position of the quinoxaline ring (PQXdpap) exhibited high catalytic activities and moderate to high selectivities (up to s = 87) in the acylative kinetic resolution of secondary alcohols. The solvent-dependent helical chirality switching of PQXdpap between pure toluene and a 1:1 mixture of toluene and 1,1,2-trichloroethane enabled the preparation of either compound of a pair of enantiomerically pure alcohols (>99% ee) from a single catalyst.

Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using an Air- and Moisture-Stable Iron Racemization Catalyst

Herein, we report on a metalloenzymatic dynamic kinetic resolution of sec-alcohols employing an iron-based racemization catalyst together with a lipase. The iron catalyst was evaluated in racemization and then used in dynamic kinetic resolution of a numbe

Ligand effect in racemization and dynamic kinetic resolution of alcohols: Mechanism on cymene ruthenium complexes

A family of ruthenium complexes with different ligands was utilized in racemization of (R)-1-phenylethanol to investigate the potential influence of the ligands coordinated to the ruthenium center. Kinetic experiments showed that 16-electron cymene ruthenium complex with two chloro-bridge bonds and 18-electron ones with easily dissociative ligands are highly active for catalytic racemization of alcohols. Possible racemization mechanism for cymene ruthenium complexes was then proposed. Computational analysis of dissociation energy barrier, NBO analysis and reaction potential energy surface suggest that ligand-dissociation process is the vital step of the racemization catalyzed by cymene ruthenium complexes. Thereafter, these complexes were applied in the DKR of secondary alcohols to verify their efficiency and applicability.