172602-83-4 Usage
Description
Ethyl 1-cyclopropyl-8-ethoxy-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate is a chemical compound that belongs to the quinoline family. It is characterized by its cyclopropyl, ethoxy, and difluoro substitutions, which contribute to its unique properties and potential applications.
Uses
Used in Pharmaceutical Industry:
Ethyl 1-cyclopropyl-8-ethoxy-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate is used as an intermediate in the synthesis of alkoxyquinolone antibacterial agents. Its presence in the synthesis process is crucial for the development of effective treatments against bacterial infections.
Used in the Synthesis of Moxifloxacin:
Ethyl 1-cyclopropyl-8-ethoxy-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate is also an impurity in the synthesis of Moxifloxacin (M745000), a fluorinated quinolone antibacterial. Moxifloxacin is a widely used antibiotic that is effective against a broad range of bacterial infections, and the presence of this compound in the synthesis process highlights its importance in the development of new and improved antibacterial agents.
Check Digit Verification of cas no
The CAS Registry Mumber 172602-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,6,0 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 172602-83:
(8*1)+(7*7)+(6*2)+(5*6)+(4*0)+(3*2)+(2*8)+(1*3)=124
124 % 10 = 4
So 172602-83-4 is a valid CAS Registry Number.
172602-83-4Relevant articles and documents
The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents
Sanchez, Joseph P.,Gogliotti, Rocco D.,Domagala, John M.,Gracheck, Stephen J.,Huband, Michael D.,et al.
, p. 4478 - 4487 (2007/10/03)
A series of 1-cyclopropyl-6-fluoro-8-alkoxy (8-methoxy and 8-ethoxy)-quinoline-3-carboxylic acids and 1-cyclopropyl-5-amino-6-fluoro-8-alkoxyquinoline-3-carboxylic acids has been prepared and evaluated for antibacterial activity.In addition, they were also compared to quinolones with classic substitution at C8 (H, F, Cl) and the naphthyridine nucleus in a phototoxicity and mammalian cell cytotoxiciry assay.The series of 8-methoxyquinolones had antibacterial activity against Gram-positive, Gram-negative, and anaerobic bacteria equivalent to that most active 8-substituted compounds (8-F and 8-Cl).There was also a concomitant reduction in several of the potential side effects (i.e., phototoxicity and clonogenicity) compared to the most active quinolones with classic substitution at C-8.The 8-ethoxy derivatives had an even better safety profile but were significantly less active (2-3 dilutions) in the antibacterial assay.
