172607-49-7Relevant articles and documents
Chiral, polyionic dendrimers with complementary charges - Synthesis and chiroptical properties
Ritzen, Andreas,Frejd, Torbjoern
, p. 3771 - 3782 (2007/10/03)
Chiral dendrimers up to the second generation have been prepared from enantiopure aromatic bis- and tris(amino acids) by peptide coupling techniques. The dendrimers could be deprotected to yield water-soluble polyamine and/or polycarboxylic acid macromolecules. Two complementary types, with respect to the charges carried in water at pH = 7, were synthesised. A chiroptical study of the protected dendrimers, which were soluble in THF and CHCl3, was conducted. The results of that study indicate that the solution shapes of these dendrimers are rather decongested, with little steric interaction between different parts of the dendritic structure.
Synthesis and authentication of iodoazidophenpyramine, a photoaffinity reporter ligand previously used for histamine H1-receptor labelling
Sorba,Tertiuk,Ganellin
, p. 677 - 680 (2007/10/03)
The synthesis is described of aminophenpyramine (7) (N-{5-[2-(4-aminophenyl)ethanamido]pentanyl}-N'-(4-methoxybenzyl)-N- methyl-N'-(2-pyridinyl)-1,2-ethandiamine), its monoiodo- and diiodo-derivatives (8 and 9), and iodoazidophenpyramine (1). The last compound is synthesised by two different routes to confirm the identity of the [125I]iodinated ligand previously made only in solution and used for characterisation of the hitamine H1-receptor protein. The procedures employ the novel intermediates 4-amino-3-iodo-phenylacetic acid (11) and 4-azido-3-iodo-phenylacetic acid (13). They have general applicability to the synthesis of non-radioactive iodinated photoaffinity receptor ligands which may be required for chemical authentication of the corresponding radiolabelled compounds.
