172733-79-8 Usage
Description
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride is a complex organic compound belonging to the class of (spiro)(hetero)cyclic amides. It is characterized by its unique spiro structure, which consists of two rings fused together in a manner that allows for interesting chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride is used as a modulator for 11-β hydroxysteroid dehydrogenase type 1 (11-β HSD1) due to its ability to interact with and regulate the enzyme's activity. This modulation can have significant implications in the treatment of various metabolic disorders and diseases related to the dysregulation of steroid hormone metabolism.
Used in Drug Development:
In the field of drug development, Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride serves as a valuable compound for the design and synthesis of novel therapeutic agents targeting 11-β HSD1. Its unique structure and functional groups can be exploited to create new drugs with improved efficacy, selectivity, and safety profiles.
Used in Research and Development:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride is also utilized in research and development settings to study the role of 11-β HSD1 in various physiological and pathological processes. This can lead to a better understanding of the enzyme's function and the potential development of targeted therapies for related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 172733-79-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,3 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 172733-79:
(8*1)+(7*7)+(6*2)+(5*7)+(4*3)+(3*3)+(2*7)+(1*9)=148
148 % 10 = 8
So 172733-79-8 is a valid CAS Registry Number.
172733-79-8Relevant articles and documents
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives
Ogino, Yoshio,Ohtake, Norikazu,Nagae, Yoshikazu,Matsuda, Kenji,Moriya, Minoru,Suga, Takuya,Ishikawa, Makoto,Kanesaka, Maki,Mitobe, Yuko,Ito, Junko,Kanno, Tetsuya,Ishihara, Akane,Iwaasa, Hisashi,Ohe, Tomoyuki,Kanatani, Akio,Fukami, Takehiro
scheme or table, p. 5010 - 5014 (2009/05/07)
Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright
MODULATORS OF MUSCARINIC RECEPTORS
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Page/Page column 71-72, (2010/11/08)
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
