172748-80-0 Usage
Description
(S)-(-)-1-(3'-chlorophenyl)propan-1-o, with the molecular formula C9H11Cl, is a chemical compound that serves as an enantiomer of 1-(3'-chlorophenyl)propan-1-o. (S)-(-)-1-(3'-chlorophenyl)propan-1-o is distinguished by its specific stereochemistry, which endows it with unique properties. It is widely recognized for its role as a chiral building block in the synthesis of pharmaceuticals and agrochemicals, making it a valuable component in the development of various drugs and chiral drug molecules. Its stereochemical properties also grant it potential applications in organic synthesis and medicinal chemistry. Furthermore, (S)-(-)-1-(3'-chlorophenyl)propan-1-o has been investigated for its pharmacological activities, which include its potential as an anti-inflammatory agent and its effects on the central nervous system.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-1-(3'-chlorophenyl)propan-1-o is used as a chiral building block for the synthesis of various pharmaceuticals. Its unique stereochemistry allows for the creation of drug molecules with specific properties, enhancing the effectiveness and targeting of medications.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-(-)-1-(3'-chlorophenyl)propan-1-o is utilized as a key intermediate in the production of various agrochemicals. Its incorporation into these products can lead to more targeted and effective pest control solutions.
Used in Organic Synthesis:
(S)-(-)-1-(3'-chlorophenyl)propan-1-o is employed as a valuable component in organic synthesis due to its stereochemical properties. This allows for the creation of a wide range of compounds with specific characteristics, contributing to the advancement of chemical research and development.
Used in Medicinal Chemistry:
(S)-(-)-1-(3'-chlorophenyl)propan-1-o is used in medicinal chemistry for its potential applications in the development of new drugs. Its unique stereochemistry can lead to the creation of more effective and targeted pharmaceuticals, improving patient outcomes.
Used as an Anti-Inflammatory Agent:
(S)-(-)-1-(3'-chlorophenyl)propan-1-o has been studied for its potential as an anti-inflammatory agent. Its pharmacological activities make it a promising candidate for the development of new treatments for inflammation-related conditions.
Used in Central Nervous System Applications:
(S)-(-)-1-(3'-chlorophenyl)propan-1-o's effects on the central nervous system have been investigated, suggesting potential applications in the development of medications targeting neurological and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 172748-80-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,7,4 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 172748-80:
(8*1)+(7*7)+(6*2)+(5*7)+(4*4)+(3*8)+(2*8)+(1*0)=160
160 % 10 = 0
So 172748-80-0 is a valid CAS Registry Number.
172748-80-0Relevant articles and documents
Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols
Cacho, Vanessa R. G.,Costa, Dora C. S.,Murtinho, Dina,Nunes, Sandra C. C.,Pais, Alberto A. C. C.,Silva Serra, M. Elisa,Tavares, Nélia C. T.
, (2022/01/08)
Taking advantage of the opposite chirality of two privileged starting materials, l-cysteine and d-penicillamine, a wide range of thiazolidine-based amino alcohols was synthesized. l-Cysteine derivatives were more efficient chiral inductors than the d-peni
Chiral P,N-ligands for the highly enantioselective addition of diethylzinc to aromatic aldehydes
Wang, Qiang,Li, Shuang,Hou, Chuan-Jin,Chu, Ting-Ting,Hu, Xiang-Ping
, (2019/08/16)
A new sterically hindered chiral P,N-ligand was synthesized and successfully applied to copper catalyzed asymmetric addition of diethylzinc to aromatic aldehydes. Various aromatic aldehydes can react smoothly to give the corresponding addition products with good to excellent enantioselectivities, which provides a readily accessible method for the preparation of chiral secondary alcohols.
Chiral thiazolidines in the enantioselective ethylation of aldehydes: An experimental and computational study
Tavares, Nélia C.T.,Neves, César T.,Milne, Bruce F.,Murtinho, Dina,Pais, Alberto A.C.C.,Serra, M. Elisa Silva
, p. 1 - 10 (2018/10/20)
A library of new chiral thiazolidines was prepared starting from L-cysteine and D-penicillamine in a simple, one-step procedure. 2-Arylthiazolidines were obtained, as diastereoisomeric mixtures, with good yields and in short reaction times, through a new and greener procedure, using microwave irradiation. Their use as chiral ligands in the enantioselective ethylation of aromatic aldehydes was studied and optimized, originating good to excellent conversions and ee up to 94% in 6 h. A series of heteroaromatic and aliphatic substrates were also enantioselectively ethylated with success, with ee up to 77%. The distinct opposite chirality in L-cysteine and D-penicillamine makes the use of these ligands an interesting approach for obtaining both the (S) and (R) enantiomers of the chiral alcohols, compounds with potential applications in the area of fine chemistry. NMR studies were carried out using a diastereoisomeric mixture of thiazolidines, allowing the identification of the most stable structure. Computational studies confirmed this result and also gave important insight into the species involved in the catalytic cycle of the enantioselective alkylation.
