172805-73-1

Basic information

• Product Name: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-hydroxy-4H-chromen-4-one
• Synonyms: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-hydroxy-4H-chromen-4-one
• CAS NO: 172805-73-1
• Molecular Weight: 480.517
• Mol File: 172805-73-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-hydroxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-hydroxy-4H-chromen-4-one(172805-73-1)
• EPA Substance Registry System: 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-hydroxy-4H-chromen-4-one(172805-73-1)

Safety Data

• Hazardous Substances Data: 172805-73-1(Hazardous Substances Data)

Upstream product

• 520-34-3 diosmetin 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 172805-74-2 7-Benzyloxy-2-(3-benzyloxy-4-methoxy-phenyl)-5-(2-hydroxy-ethoxy)-chromen-4-one 
• 172805-75-3 [7-Benzyloxy-2-(3-benzyloxy-4-methoxy-phenyl)-4-oxo-4H-chromen-5-yloxy]-acetic acid ethyl ester 
• 1094471-10-9 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-trifluoromethanesulfonyloxy-4H-chromen-4-one 

Relevant articles and documents

A convenient microwave-assisted 5-amination of flavones

A few examples of 5-aminoflavones' syntheses exist in the literature and for those, which are described, the amino group is introduced before the formation of the flavone skeleton. We describe here an efficient method, which permits the access to 5-aminoflavones by a simple procedure using an SNAr amination under microwaves irradiation.

Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships

A series of 28 flavonoid derivatives containing a N-benzylpiperazine chain have been synthesized and tested for their ability to modulate multidrug resistance (MDR) in vitro. At 5 μM, most compounds potentiated doxorubicin cytotoxicity on resistant K562/DOX cells. They were also able to increase the intracellular accumulation of JC-1, a fluorescent molecule recently described as a probe of P-glycoprotein-mediated MDR. This suggests that these compounds act, at least in part, by inhibiting P-glycoprotein activity. As in other studies, lipophilicity was shown to influence MDR- modulating activity but was not the only determinant. Diverse di- and trimethoxy substitutions on N-benzyl were examined and found to affect the activity differently. The most active compounds had a 2,3,4- trimethoxybenzylpiperazine chain attached to either a flavone or a flavanone moiety (13, 19, 33, and 37) and were found to be more potent than verapamil.