172821-93-1

Basic information

• Product Name: 4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate
• Synonyms: 4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate
• CAS NO: 172821-93-1
• Molecular Formula: C15H16O5
• Molecular Weight: 276.28454
• Mol File: 172821-93-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate(172821-93-1)
• EPA Substance Registry System: 4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate(172821-93-1)

Safety Data

• Hazardous Substances Data: 172821-93-1(Hazardous Substances Data)

Upstream product

• 39746-01-5 (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one 
• 101208-17-7 (3aR,4S,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(triphenylmethoxy)methyl]-2H-cyclopenta[b]furan-2-one 
• 58707-50-9 (3aR,4S,5R,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one 
• 32233-40-2 (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 
• 65-85-0 benzoic acid 
• 39746-00-4 (1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one 
• 131543-60-7 (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-4-(iodomethyl)-2H-cyclopentafuran-2-one 
• 521323-11-5 corey lactone diol 
• 98-88-4 benzoyl chloride 

Downstream Products

• 39968-95-1 (3aR,4S,5R,6aS)-5-[(tert-butyldimethylsilyl)oxy]-4-(hydroxymethyl)-hexahydro-2H-cyclopenta[b]furan-2-one 
• 94595-91-2 (1R,5S,6S,7R)-3-oxo-6-hydroxymethyl-7-hydroxybicyclo<3.3.0>octane 
• 69552-46-1 (5E)-carba-PGI2 
• 64927-55-5 (3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 136790-75-5 (Z)-7-((1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl)hept-5-enoic acid 
• 136790-77-7 (Z)-benzyl 7-((1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl)hept-5-enoate 
• 333963-40-9 lubiprostone 
• 1064596-51-5 (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(1E,3S)-3-hydroxy-4-methyl-1-octenyl]-2H-cyclopenta[b]furan-2-one 
• 1064596-55-9 (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(1E,3R)-3-hydroxy-4-methyl-1-octenyl]-2H-cyclopenta[b]furan-2-one 
• 1065008-64-1 (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-4-[(1E)-4-methyl-3-oxo-1-octenyl]-2H-cyclopenta[b]furan-2-one 

Relevant articles and documents

Method for preparing substituted benzoyl Corey lactone by one-step method

The invention belongs to the technical field of organic chemistry, and particularly relates to a method for preparing substituted benzoyl Corey lactone by a one-step method. The method comprises the following steps of: adding Corey lactone diol serving as a raw material into a pre-stirred catalytic reaction system of metal copper salt and N,O-ligand, adding alkali required by reaction into the reaction mixed system, and finally adding substituted benzoyl chloride to carry out acylation reaction at a secondary hydroxyl position, so as to efficiently prepare the substituted benzoyl Corey lactone by a one-step method. The method has the advantages of high efficiency, convenience, simplicity in operation, mild reaction conditions, cheap and easily available metals and ligands, high reaction regioselectivity, avoiding of the use of a primary alcohol protective agent, cost reduction and suitableness for industrial preparation.

One-pot method of preparing benzoyl the branch stands lactone (by machine translation)

The present invention discloses a one-pot method for preparing benzoyl the branch stands lactone. At the same in the reaction container, to the branch stands lactone diol as raw materials, adding solvent S1 And triphenyl methyl chloride to primary hydroxyl position of the alkylation reaction, to obtain [...] lactone solvent S [...] hydroxy derivatives1 The reaction system, benzoyl chloride to continue adding hydroxyl position of acylation reaction, and adding solvent S2 , Recrystallization, get the branch stands lactone glycol double-hydroxy derivative; adding solvent S3 And acid solution hydrolysis reaction of the primary hydroxyl group position, make the branch stands lactone crude benzoyl; adding solvent S4 Or/and S5 , Recrystallization, disposable and preparing the corresponding optically active benzoyl the branch stands lactone. The invention avoid each step reaction is repeatedly re-feeding the tedious; adequate reaction, little side reaction, high purity; after treatment is simple, high yield; and the operation is simple, time saving and high efficiency, saving the material, reducing the cost, and is suitable for industrial production. (by machine translation)

Preparing method for benzoyl corey lactone

The invention provides a method for preparing a high-purity compound shown in a formula 3. The preparing method includes the steps that in dichloromethane, in the presence of diisopropylethylamine, primary alcohol of (-)-corey lactone shown in a formula 4 is protected with triethylchloro-silicane to obtain the compound shown in the formula 3; in the formula, R is the triethylchloro-silicane, wherein the molar ratio of the (-)-corey lactone shown in the formula 4 to the triethylchloro-silicane is 1-1.5, the molar ratio of the (-)-corey lactone shown in the formula 4 to the diisopropylethylamineis 1.5-3, and the mass/the volume (g/ml) of the (-)-corey lactone shown in the formula 4 to the dichloromethane is 3-10; the reaction temperature is 20 DEG C to 30 DEG C. The invention also providesa method for preparing benzoyl corey lactone shown in the formula 1 with the obtained high-purity compound shown in the formula 3. The method is good in selectivity, convenient to use and easy to industrialize, and therefore the (-)-corey lactone can be prepared at high yield. The formula is defined in the description.