172885-53-9

Basic information

• Product Name: (S)-2-IodoMethyl-pyrrolidine-1-carboxylic acid benzyl ester
• Synonyms: (S)-2-IodoMethyl-pyrrolidine-1-carboxylic acid benzyl ester
• CAS NO: 172885-53-9
• Molecular Formula: C₁₃H₁₆INO₂
• Molecular Weight: 345.17611
• Mol File: 172885-53-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-IodoMethyl-pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-IodoMethyl-pyrrolidine-1-carboxylic acid benzyl ester(172885-53-9)
• EPA Substance Registry System: (S)-2-IodoMethyl-pyrrolidine-1-carboxylic acid benzyl ester(172885-53-9)

Safety Data

• Hazardous Substances Data: 172885-53-9(Hazardous Substances Data)

Upstream product

• 123803-29-2 (S)-benzyl 2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate 
• 6216-63-3 N-Cbz-Prolinol 
• 501-53-1 benzyl chloroformate 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 172885-54-0 (S)-2-(Dimethoxy-phosphorylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-73-1 (S)-phenylmethyl 2-(mercaptomethyl)-1-pyrrolidinecarboxylate 
• 1638689-33-4 C₁₆H₁₈N₄O₄ 
• 141774-67-6 (S)-benzyl 2-(azidomethyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni's Reagent

This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl-CF3 products with excellent functional group tolerance and broad substrate scope. A mechanism involving a reaction of alkyl-Cu with Togni's reagent was proposed.

Novel cyclic β-aminophosphonate derivatives as efficient organocatalysts for the asymmetric Michael addition reactions of ketones to nitrostyrenes

Three novel catalysts based upon cyclic β-aminophosphonate derivatives 13 were designed to catalyze the asymmetric Michael addition reactions of ketones to β-nitrostyrenes. Among the catalysts that have been prepared in this study, cyclic β-aminophosphonic acid monoethylester 3 showed the highest catalytic ability, giving the corresponding Michael adduct in good yields, high enantioselectivities (up to 92%ee), and high diastereoselectivities (syn:anti up to 95:5).