172899-48-8

Basic information

• Product Name: b-Alanine, N-(4-aminobenzoyl)-, ethyl ester
• CAS NO: 172899-48-8
• Molecular Formula: C12H16N2O3
• Molecular Weight: 236.271
• Mol File: 172899-48-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: b-Alanine, N-(4-aminobenzoyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: b-Alanine, N-(4-aminobenzoyl)-, ethyl ester(172899-48-8)
• EPA Substance Registry System: b-Alanine, N-(4-aminobenzoyl)-, ethyl ester(172899-48-8)

Safety Data

• Hazardous Substances Data: 172899-48-8(Hazardous Substances Data)

Upstream product

• 4244-84-2 ethyl β-alaninate hydrochloride 
• 150-13-0 4-amino-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 719289-62-0 3-{4-[(9H-fluoren-2-ylmethyl)amino]benzoylamino}propionic acid ethyl ester 
• 67726-36-7 N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-β-alanine ethyl ester 
• 67726-33-4 N-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine ethyl ester 
• 67726-30-1 N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine ethyl ester 

Relevant articles and documents

Synthesis and anti-diabetic activity of novel biphenylsulfonamides as glucagon receptor antagonists

Type 2 diabetes is characterized by chronic hyperglycemia. Insulin, a hormone secreted from pancreatic β-cells, decreases blood glucose levels, and glucagon, a hormone secreted from pancreatic α-cells, increases blood glucose levels by counterregulation of insulin through stimulation of hepatic glucose production. In diabetic patients, dysregulation of glucagon secretion contributes to hyperglycemia. Thus, inhibition of the glucagon receptor is one strategy for the treatment of hyperglycemia in type 2 diabetes. In this paper, we report a series of biphenylsulfonamide derivatives that were designed, synthesized, and then evaluated by cAMP and hepatic glucose production assays as glucagon receptor antagonists. Of these, compound 7aB-3 decreased glucagon-induced cAMP production and glucagon-induced glucose production in the in vitro assays. Glucagon challenge tests and glucose tolerance tests showed that compound 7aB-3 significantly inhibited glucagon-induced glucose increases and improved glucose tolerance. These results suggest that compound 7aB-3 has therapeutic potential for the treatment of type 2 diabetes.