173031-14-6Relevant articles and documents
New cyclohexyl-based chiral auxiliaries: Enantioselective synthesis of α-hydroxy acids
Basavaiah, Deevi,Krishna, Peddinti Rama
, p. 12169 - 12178 (1995)
(1R,2R)-2-(4-tert-butylphenoxy) cyclohexan-1-ol (5) and (1R,2R)-2-(4-phenylphenoxy) cyclohexan-1-ol (6) have been used for the first time as chiral auxiliaries. Addition of alkylzinc chlorides to the corresponding glyoxylates 5a, 6a, after hydrolysis, provided (R)-α-hydroxy acids in high optical purities.