173037-24-6

Basic information

• Product Name: diethyl N-<4-(trans-2<(t-butyldimethylsilyloxy)methyl>cyclobutyl)benzoyl>-L-glutamate
• Synonyms: diethyl N-<4-(trans-2<(t-butyldimethylsilyloxy)methyl>cyclobutyl)benzoyl>-L-glutamate
• CAS NO: 173037-24-6
• Molecular Weight: 505.727
• Mol File: 173037-24-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl N-<4-(trans-2<(t-butyldimethylsilyloxy)methyl>cyclobutyl)benzoyl>-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-<4-(trans-2<(t-butyldimethylsilyloxy)methyl>cyclobutyl)benzoyl>-L-glutamate(173037-24-6)
• EPA Substance Registry System: diethyl N-<4-(trans-2<(t-butyldimethylsilyloxy)methyl>cyclobutyl)benzoyl>-L-glutamate(173037-24-6)

Safety Data

• Hazardous Substances Data: 173037-24-6(Hazardous Substances Data)

Upstream product

• 173037-27-9 ethyl 2-(4-bromophenyl)cyclobutane-1-carboxylate 
• 173037-26-8 1-bromo-4-(1-bromo-3-chloropropyl)benzene 
• 31736-73-9 4-bromophenyl 2-chloroethyl ketone 
• 1118-89-4 diethyl-L-glutamate hydrochloride 

Downstream Products

• 173037-34-8 diethyl N-<4-(trans-2-<(<2,6-diamino-4-(3H)-oxopyrimidin-5-yl>thio)methyl>cyclobutyl)benzoyl>L-glutamate 
• 173037-25-7 diethyl N-<4-(trans-2-<(acetylthio)methyl>cyclobutyl)benzoyl>-L-glutamate 
• 173037-31-5 diethyl N-<4-(trans-2-cyclobutyl)benzoyl>-L-glutamate 

Relevant articles and documents

Synthesis and biological evaluation of N-[4-(2-trans-[([2,6-diamino-4(3H)-oxopyrimidin-5-yl]methyl)thio]cyclo butyl)benzoyl]-L-glutamic acid a novel 5-thiepyrimidinone inhibitor of dihydrofolate reductase

The synthesis and biological evaluation of N-[4-(2-trans-[([2,6-diamino-4(3H)-oxopyrimidin-5-yl]methyl)thio]cyclo butyl)benzoyl]-L-glutamic acid (1) is reported. Compound 1 is a potent dihydrofolate reductase (DHFR) inhibitor (K(i) = 12 nM) with excellent