173171-93-2Relevant articles and documents
A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature
Sabitha, Gowravaram,Reddy, G.S. Kiran Kumar,Reddy, Ch. Srinivas,Yadav
, p. 4129 - 4131 (2003)
The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature in the presence of iodotrimethylsilane (TMSI) generated in situ in CH3CN, in excellent yields.
Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies
Ajana, Mohammed Aziz,Anouar, El Hassane,Berdimurodov, Elyor,Hajji, Halima,Hichar, Abdelhadi,Lakhrissi, Brahim,Oubihi, Asmaa,Rbaa, Mohamed,Tüzün, Burak,Zarrouk, Abdelkader
, (2021/06/30)
The present study aims to first explore the relationship between the chemical structure of the organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities, as well as the impact of substituent effects on their antibacterial properties. These compounds were synthesized by efficient methods, and their structures confirmed by the spectral methods (IR, 1H NMR, 13C NMR and elemental analysis). The antibacterial activities of synthesized the compounds were checked with five Gram-positive and Gram-negative strains such as Enterobacter cloacae (ATCC29893),Escherichia coli (ATCC35218), Klebsiella pneumoniae (ATCC13883), Staphylococcus aureus (ATCC29213) and Acinetobacter baumannii (ATCC19606). The results of the antibacterial activities of four synthesized compounds were compared with three standard antibiotics [Penicillin G, Erythromycin and Norfloxacin (quinoline type)]. The minimum inhibitory concentrations (MICs) of active compounds were calculated and discussed. The chemical and biological activities of hydroxyquinoline derivatives were compared with theoretical methods. The chemical activities of hydroxyquinoline derivatives were contrasted with the important quantum chemical parameters using the HF/6–31++g (d, p) basis sets. Besides, biological activities of hydroxyquinoline derivatives against cancer proteins that are respectively protein of the BRCT repeat region of breast cancer that is ID: 1JNX, crystal structure of liver cancer protein that is ID: 3WZE, and crystal structure of lung cancer protein that is ID: 5ZMA, were compared. ADME/T (Adsorption, Distribution, Metabolism, Excretion, and Toxicity) analysis was studied for molecules with high biological activity to become efficient drugs in the future.
Cu-doped ZnO nanocrystalline powder as a catalyst for green and convenient multi-component synthesis of 1,4-dihydropyridine
Alinezhad, Heshmatollah,Mohseni Tavakkoli, Sahar
, p. 5931 - 5940 (2015/08/18)
Abstract A simple, efficient, and convenient one-step method for synthesis of Hantzsch 1,4-dihydropyridine, using Cu-doped ZnO nanocrystalline powder as a catalyst is reported. The method offers several advantages including excellent yields, green solvent, easy work-up, simplicity in operation and catalyst reusability.
Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters
Radadiya, Ashish,Khedkar, Vijay,Bavishi, Abhay,Vala, Hardevsinh,Thakrar, Shailesh,Bhavsar, Dhairya,Shah, Anamik,Coutinho, Evans
, p. 375 - 387 (2014/02/14)
A series of symmetrical and unsymmetrical 1,4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compound
