17322-82-6

Basic information

• Product Name: (3aR,4aα,9aα)-Dodecahydro-6α-hydroxy-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2-one
• Synonyms: (+)-Isotelekin;(3aR,4aα,9aα)-Dodecahydro-6α-hydroxy-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2-one
• CAS NO: 17322-82-6
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.3175
• Mol File: 17322-82-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3aR,4aα,9aα)-Dodecahydro-6α-hydroxy-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,4aα,9aα)-Dodecahydro-6α-hydroxy-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2-one(17322-82-6)
• EPA Substance Registry System: (3aR,4aα,9aα)-Dodecahydro-6α-hydroxy-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2-one(17322-82-6)

Safety Data

• Hazardous Substances Data: 17322-82-6(Hazardous Substances Data)

Upstream product

• 470-17-7 isoalantolactone 

Relevant articles and documents

Structural investigation and biological activity of sesquiterpene lactones from the Traditional Chinese Herb Inula racemosa

Five new sesquiterpene lactones, racemosalactones A-E (1-5), along with 19 known sesquiterpene latones (6-24), were isolated from the roots of Inula racemosa. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 2 was deduced from X-ray diffraction analysis. Compounds 1, 6, 8, 10, 12, 14, and 17 exhibited antiproliferative activities with IC50 values ranging from 0.38 to 4.19 μg/mL against human non-small-cell lung cancer A549, hepatocellular carcinoma HepG2, and human fibrosarcoma HT1080 cells. Compounds 6 and 8 exhibited antiproliferative activities against endothelial cells with IC50 values of 2.4 and 2.5 μg/mL, respectively. Furthermore, compounds 6 and 8 both inhibited endothelial cell tube formation at 1.0 μg/mL. A method for the rapid and straightforward preparative-scale isolation of compound 6 from alantolides is described.

Isolation, Chemical Transformation, and Antifungal Potential of Sesquiterpene Lactones from Inula Racemosa

The present study reports the isolation of two eudesmanolide type sesquiterpenoid lactones, viz. alantolactone and isoalantolactone, from the roots of Inula racemosa Hook L. and their chemical transformations using various reagents. All the compounds isol

Isoalantolactone derivative, pharmaceutical composition and application thereof

The invention relates to an isoalantolactone derivative, a pharmaceutical composition and application thereof, especially use of the isoalantolactone derivative shown as formula (I) or a salt pharmaceutical compound thereof in preparation of adjuvant drugs treating cancer, a pharmaceutical composition containing a therapeutically effective amount of isoalantolactone derivative (I) or its salt anda pharmaceutically acceptable carrier or a composition with other anticancer drugs.