17328-67-5

Basic information

• Product Name: Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-
• CAS NO: 17328-67-5
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Mol File: 17328-67-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-(17328-67-5)
• EPA Substance Registry System: Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-(17328-67-5)

Safety Data

• Hazardous Substances Data: 17328-67-5(Hazardous Substances Data)

Upstream product

• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 5432-85-9 4-isopropyl-cyclohexanone 
• 38651-65-9 (1R,5S)-(+)-nopinone 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 917-54-4 methyllithium 

Relevant articles and documents

Fluorination or hydroxylation of non activated C-H bonds in amides and ketones using CCl4 or NBS in superacids

Amides and ketones are fluorinated or hydroxylated in HF-SbF5 in the presence of CCl4 or NBS, reaction occurring at a carbon far located from the functional group.

CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I). Wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

Functionalization of non-activated C-H bonds in ketones and imines with HF/SbF5/CCl4

Reaction of cyclic ketones 2-6 and imines 15-17 in HF/SbF5 in presence of CCl4 yield hydroxy or fluoroderivatives, hydride abstraction occurring at a site located far from the functional group. Whereas ketones 2-5 yield only hydroxy derivatives, through cyclic carboxonium ion, imines 15, 16 N-protonated in the media conditions give only fluoroderivatives 18, 19, respectively, after quenching with HF-pyridine. Ring contraction is operative when starting from large membered ring ketones 24 and 25, and imine 26, leading to a mixture of hydroxy or fluoro cyclohexanones and/or cycloheptanones.