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17331-67-8

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17331-67-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17331-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,3 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17331-67:
(7*1)+(6*7)+(5*3)+(4*3)+(3*1)+(2*6)+(1*7)=98
98 % 10 = 8
So 17331-67-8 is a valid CAS Registry Number.

17331-67-8Relevant articles and documents

PREPARATION OF 5'-O-PHOSPHONYLMETHYL ANALOGUES OF NUCLEOSIDE-5'-PHOSPHATES, 5'-DIPHOSPHATES AND 5'-TRIPHOSPHATES

Holy, Antonin,Rosenberg, Ivan

, p. 3447 - 3463 (2007/10/02)

Reaction of a trialkyl phosphite (VI) or sodium salt of dialkyl phosphite (V) with bromomethyl acetate afforded dialkyl acetoxymethanephosphonates VII which were alcoholyzed to dialkyl hydroxymethanephosphonates VIII.Tosylation of the compounds VIII gave dialkyl p-toluenesulfonyloxymethanephosphonates IX which on reaction with 2',3'-O-isopropylideneribonucleosides (I), 2',3'-O-ethoxymethyleneribonucleosides (XI) or 3'-O-tetrahydropyranyl-2'-deoxyribonucleosides in the presence of sodium hydride, followed by acid hydrolysis, were converted into alkyl esters of 5'-O-phosphonylmethylnucleosides XII.Treatment of compounds XII with trimethylsilyl iodide led to 5'-O-phosphonylmethylnucleosides II and XIV.The ribo derivatives II were also obtained in low yields by reaction of compounds I with sodium chloromethanephosphonate in the presence of sodium hydride.Compound II reacted with morpholine in the presence of N,N'-dicyclohexylcarbodiimide to give morpholides XV which on treatment with phosphate afforded 5'-O-phosphorylphosphonylmethylribonucleosides XVI.Analogously, 5'-O-diphosphorylphosphonylmethylribonucleosides XVII were obtained from the derivatives XV by reaction with diphosphate.The compounds II are resistant towards E. coli alkaline phosphomonoesterase and snake venom and bull semen 5'-nucleotidase.E. coli alkaline phosphomonoesterase degrades the compounds XVI and XVII to compounds II and inorganic phosphate.

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