173348-63-5

Basic information

• Product Name: 2-acetoxy-5-hydroxy-p-benzoquinone
• CAS NO: 173348-63-5
• Molecular Weight: 182.133
• Mol File: 173348-63-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-acetoxy-5-hydroxy-p-benzoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetoxy-5-hydroxy-p-benzoquinone(173348-63-5)
• EPA Substance Registry System: 2-acetoxy-5-hydroxy-p-benzoquinone(173348-63-5)

Safety Data

• Hazardous Substances Data: 173348-63-5(Hazardous Substances Data)

Upstream product

• 16523-32-3 2,5-diacetoxy-1,4-benzoquinone 

Downstream Products

• 213831-86-8 2-acetoxy-5-methoxy-[1,4]benzoquinone 
• 5691-70-3 2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione 
• 3117-03-1 2,5-dimethoxyquinone 

Relevant articles and documents

Preparation and structure-activity relationships of novel asterriquinone derivatives

Asterriquinone (ARQ, la) is an antitumor metabolite of Aspergillus terreus IFO 6123. To gain insight into the structure-activity relationships of ARQ, a series of chemically modified derivatives (1 - 6), the ARQ analogues (b - e) and the 2,5-dihydroxy-p-benzoquinone analogues (f - h), were prepared, and cytotoxic activity against mouse leukemia P388 cells investigated. Results indicated that: 1) at least one hydroxy group or acetoxy group in the p-benzoquinone moiety is important to exhibit cytotoxicity; 2) in the p-benzoquinone moiety, a single methoxy group and/or one acetoxy group substitution showed more potent cytotoxicity than when two hydroxy groups are substituted (1); 3) the indole ring is important for the cytotoxicity of ARQ analogues; 4) the 1,1-dimethyl-2-propenyl group in the indole ring is not important for the cytotoxic activity of ARQ.