173406-70-7

Basic information

• Product Name: 3-BROMO-N-HYDROXY-BENZAMIDINE
• Synonyms: 3-BROMO-N-HYDROXY-BENZAMIDINE;(E)-3-Bromo-N'-hydroxybenzimidamide;3-broMo-N'-hydroxybenzene-1-carboxiMidaMide;3-bromo-N-hydroxybenzimidamide
• CAS NO: 173406-70-7
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• Mol File: 173406-70-7.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BROMO-N-HYDROXY-BENZAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-N-HYDROXY-BENZAMIDINE(173406-70-7)
• EPA Substance Registry System: 3-BROMO-N-HYDROXY-BENZAMIDINE(173406-70-7)

Safety Data

• Hazardous Substances Data: 173406-70-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-N-hydroxy-benzamidine is a chemical compound that belongs to the class of benzamidines. It is an organic compound with the molecular formula C7H7BrN2O and a molecular weight of 214.05 g/mol. 3-BROMO-N-HYDROXY-BENZAMIDINE is a bromo-substituted derivative of N-hydroxy-benzamidine and is commonly used as a reagent in organic synthesis and pharmaceutical research. It is also known for its potential use as an anticoagulant and anti-thrombotic agent. 3-Bromo-N-hydroxy-benzamidine is a white to off-white solid that is sparingly soluble in water, and its precise chemical properties make it a valuable component in various chemical and pharmaceutical applications.

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 3132-99-8 m-bromobenzoic aldehyde 
• 51873-95-1 3-bromobenzaldehyde oxime 

Downstream Products

• 160377-57-1 3-(3-bromophenyl)-5-methyl-1,2,4-oxadiazole 
• 1196463-20-3 C₁₂H₁₃BrN₂O₄ 
• 904523-92-8 N'-(acetyloxy)-3-bromobenzenecarboximidamide 
• 1424313-41-6 2-(3-bromophenyl)-5-oxo-5H-chromeno[4,3-d]pyrimidine-3-oxide 
• 1430424-11-5 C₂₁H₁₉BrClN₃O₂ 
• 1572343-36-2 3-(3-(9H-[3,9'-bicarbazol]-9-yl)phenyl)-5-phenyl-1,2,4-oxadiazole 
• 1003221-10-0 3-(3-bromophenyl)-5-phenyl-1,2,4-oxadiazole 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

KCNT1 INHIBITORS AND METHODS OF USE

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.