173435-32-0

Basic information

• Product Name: 3-AMINO-2-FLUORO-4-PICOLINE
• Synonyms: 3-AMINO-2-FLUORO-4-METHYLPYRIDINE;3-AMINO-2-FLUORO-4-PICOLINE;2-FLUORO-4-METHYLPYRIDIN-3-AMINE;2-Fluoro-4-methyl-pyridin-3-ylamine;3-Pyridinamine,2-fluoro-4-methyl-(9CI);2-Fluoro-4-methyl-3-pyridinamine;3-Amino-2-fluoro-4-methylpyridin;3-Pyridinamine,2-fluoro-4-methyl-
• CAS NO: 173435-32-0
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.13
• EINECS: 241-372-6
• Product Categories: AMINEPRIMARY;PYRIDINE;Pyridines
• Mol File: 173435-32-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63-64℃
• Boiling Point: 260.8 °C at 760 mmHg
• Flash Point: 111.5 °C
• Appearance: Off-white/Solid
• Density: 1.196 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.16±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-2-FLUORO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-FLUORO-4-PICOLINE(173435-32-0)
• EPA Substance Registry System: 3-AMINO-2-FLUORO-4-PICOLINE(173435-32-0)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 173435-32-0(Hazardous Substances Data)

Usage

Description

3-AMINO-2-FLUORO-4-PICOLINE, also known as 2-Fluoro-4-methylpyridin-3-amine, is an organic compound with a unique molecular structure that features a fluorine atom and an amino group. It is a versatile building block in the synthesis of various pharmaceutical compounds due to its distinct chemical properties.

Uses

Used in Pharmaceutical Industry:
3-AMINO-2-FLUORO-4-PICOLINE is used as a key reactant for the synthesis of various compounds, such as phenylsulfonamidomethylbenzamides, oxopyridopyrrolopyrazinyacetamides, carbamoylalkylthiophenylmethylpicolinamides, and benzylthiotriazolylpyridines. These synthesized compounds exhibit significant structure-activity relationships (SAR) and have been found to possess both agonistic and antagonistic activities towards the kappa opioid receptor. This makes 3-AMINO-2-FLUORO-4-PICOLINE a valuable component in the development of novel therapeutic agents targeting the opioid system for pain management and other related conditions.

InChI:InChI=1/F6Si.2Li/c1-7(2,3,4,5)6;;/q-2;2*+1

Upstream product

• 19346-43-1 2-fluoro-4-methyl-3-nitropyridine 

Downstream Products

• 1355244-02-8 ML 190 

Relevant articles and documents

N-aryl[1,2,4]triazolo[1,5-a]pyrazine-2-sulfonamide herbicides

Substituted N-aryl[1,2,4]triazolo[1,5-a]-pyrazine-2-sulfonamide compounds, such as 5-bromo-N-(2,6-dichlorophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]-pyrazine-2-sulfonamide, were prepared by condensation of a substituted 2-chlorosulfonyl[1,2,4]triazolo[1,5-a]pyrazine compound, such as 5-bromo-2-chlorosulfonyl-8-methoxy[1,2,4]triazolo[1,5-a]pyrazine with a substituted arylamine compound, such as 2,6-dichloroaniline, and found to possess herbicidal utility.

Ring annulated 5-alkoxy-n-aryl[1,2,4]triazolo[1,5-C]-pyrimidine-2-sulfonamide herbicides

Substituted ring annulated 5-alkoxy-N-aryl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide compounds, such as N-(2,6-dichlorophenyl)-5-methoxycyclopenteno[d]-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of an appropriate 2-chloro-sulfonyl-5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-5-methoxycyclopenteno[d][1,2,4]triazolo[1,5-c]pyrimidine, with a substituted arylamine compound, such as 2,6-dichloroaniline, and found to possess herbicidal utility.

N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides

Substituted N-pyridinyl[1,2,4]triazolo[1,5-c]-pyrimidine-2-sulfonamide compounds, such as N-(2-fluoro-4-methyl)-7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine, with a substituted 3-aminopyridine compound, such as 3-amino-2-fluoro-4-methylpyridine, and found to possess herbicidal utility.