173457-29-9

Basic information

• Product Name: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester
• Synonyms: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester
• CAS NO: 173457-29-9
• Molecular Weight: 259.132
• Mol File: 173457-29-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester(173457-29-9)
• EPA Substance Registry System: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester(173457-29-9)

Safety Data

• Hazardous Substances Data: 173457-29-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 79333-48-5 2-(S)-(3,4-dichloro-phenyl)-4-pentenoic acid 
• 7226-23-5 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 
• 106-95-6 allyl bromide 
• 6725-44-6 methyl 2-(3,4-dichlorophenyl)acetate 
• 556-56-9 allyl iodid 
• 5807-30-7 3,4-dichlorophenyl acetic acid 

Downstream Products

• 1563182-47-7 (R)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 
• 1563182-50-2 (S)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 
• 1563182-54-6 (R)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester 
• 1563182-91-1 (R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-2-methylbutanoic acid 
• 1563182-55-7 (S)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester 
• 1563182-92-2 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-2-methylbutanamido)-2-phenylacetamido)ethyl carbamic acid tert-butyl ester 
• 1563182-93-3 (R)-2-(trimethylsilyl)ethyl 2-(3,4-dichlorophenyl)-2-methyl-4-(4-(N-propylmethylsulfonamido)piperidin-1-yl)butanoate 
• 1563182-94-4 (S)-2-(trimethylsilyl)ethyl 2-(3,4-dichlorophenyl)-2-methyl-4-(4-(N-propylmethylsulfonamido)piperidin-1-yl)butanoate 
• 1563182-95-5 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-2-methyl-4-(4-(N-propylmethylsulfonamido)piperidin-1-yl)butanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563182-96-6 2-((S)-2-((S)-2-(3,4-dichlorophenyl)-2-methyl-4-(4-(N-propylmethylsulfonamido)piperidin-1-yl)butanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563182-97-7 (R)-2-(3,4-dichlorophenyl)-2-methyl-4-(1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-yl)butanoic acid 
• 1563182-90-0 (R)-3-(3,4-dichlorophenyl)-5-hydroxy-3-methyldihydrofuran-2(3H)-one 
• 1563182-56-8 (R)-2-(trimethylsilyl)ethyl 2-(3,4-dichlorophenyl)-2-methyl-4-oxobutanoate 
• 1563182-99-9 (S)-2-(3,4-dichlorophenyl)-2-methyl-4-(1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-yl)butanoic acid 

Relevant articles and documents

Design, synthesis, and optimization of balanced dual NK1/NK 3 receptor antagonists

In connection with a program directed at potent and balanced dual NK 1/NK3 receptor ligands, a focused exploration of an original class of peptidomimetic derivatives was performed. The rational design and molecular hybridization of a novel phenylalanine core series was achieved to maximize the in vitro affinity and antagonism at both human NK1 and NK3 receptors. This study led to the identification of a new potent dual NK1/NK3 antagonist with pKi values of 8.6 and 8.1, respectively.

Synthesis and structure-antifungal activity relationships of 3-aryl-5-alkyl-2,5-dihydrofuran-2-ones and their carbanalogues: Further refinement of tentative pharmacophore group

Two series of 3-(substituted phenyl)-5-alkyl-2,5-dihydrofuran-2-ones related to a natural product, (-)incrustoporine, were synthesized and their in vitro antifungal activity evaluated. The compounds with halogen substituents on the phenyl ring exhibited selective antifungal activity against the filamentous strains of Absidia corymbifera and Aspergillus fumigatus. On the other hand, the influence of the lenghth of the alkyl chain at C(5) was marginal. The antifungal effect of the most active compound against the above strains was higher than that of ketoconazole, and close to that of amphotericin B. In order to verify the hypothesis about a possible relationship between the Michael-accepting ability of the compounds and their antifungal activity, a series of simple carbanalogues, 2-(substituted phenyl)cyclopent-2-enones, was prepared and subjected to antifungal activity assay as well.

3-Phenyl-5-methyl-2H,5H-furan-2-ones: Tuning antifungal activity by varying substituents on the phenyl ring

A series of racemic 3-phenyl-5-methyl-2H,5H-furan-2-ones related to a natural product, (-)incrustoporine, was synthesized, and their antifungal activity evaluated. The key structural feature, furanone ring, was closed via H2SO4-mediated cyclization of 2-phenylpent-4-enoic acids. The compounds displayed antifungal activity, especially against filamentous fungi. Expressed as the minimum inhibition concentration (MIC) in μmol/L, the activity of the most promising derivative against Absidia corymbifera matched that of ketoconazole (31.25 μmol/L). In terms of μg/mL, the substance was more active (7.6 μg/mL) than this standard antifungal drug (16.6 μg/mL). (C) 2000 Elsevier Science Ltd. All rights reserved.