1736-74-9Relevant articles and documents
ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND
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, (2021/10/22)
The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.
Mild oxidation of benzyl alcohols to benzyl aldehydes or ketones catalyzed by visible light
Cheng, Dongping,Li, Xiaonian,Ren, Shujian,Xu, Xiaoliang
supporting information, (2021/07/02)
Induced by visible light, mild oxidation condition to prepare benzyl aldehydes or ketones have been developed by using bromotrichloromethane as photochemical oxidant. This method avoids high temperature, pressure and peroxidation with only visible light as the green driving force.
A method of synthesis of primary alcohol (by machine translation)
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Paragraph 0099; 0100; 0101; 0102; 0103, (2019/03/17)
The invention discloses a method for synthesizing a primary alcohol, using transition metal catalysis, the use of isopropanol as a hydrogen source to synthesize primary alcohol, the reaction not only using a cheap, environmental protection of isopropanol as a hydrogen source and solvent, and has high yield, environmental protection and the like, so that the reaction has broad prospects for development. (by machine translation)