17361-89-6

Basic information

• Product Name: 5-PHENYL-2-THIOPHENECARBONYL CHLORIDE
• Synonyms: 5-Phenylthiophene-2-carbonyl chloride;2-(Chlorocarbonyl)-5-phenylthiophene, 2-(Chloroformyl)-5-phenylthiophene;5-PHENYL-2-THIOPHENECARBONYL CHLORIDE;BUTTPARK 98\04-17
• CAS NO: 17361-89-6
• Molecular Formula: C₁₁H₇ClOS
• Molecular Weight: 222.69
• Mol File: 17361-89-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 347.9 °C at 760 mmHg
• Flash Point: 164.2 °C
• Appearance: /
• Density: 1.305 g/cm³
• Vapor Pressure: 5.23E-05mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 5-PHENYL-2-THIOPHENECARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-2-THIOPHENECARBONYL CHLORIDE(17361-89-6)
• EPA Substance Registry System: 5-PHENYL-2-THIOPHENECARBONYL CHLORIDE(17361-89-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• Hazardous Substances Data: 17361-89-6(Hazardous Substances Data)

Usage

General Description

5-Phenyl-2-thiophenecarbonyl chloride is a chemical compound with the molecular formula C12H7ClOS. It is a reactive and highly versatile compound that is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is a type of acyl chloride, which means it contains a carbonyl group and a chlorine atom attached to a phenyl and thiophene ring. 5-PHENYL-2-THIOPHENECARBONYL CHLORIDE is highly reactive and can easily undergo nucleophilic substitution reactions, making it useful in a wide range of organic synthesis processes. Additionally, it is important to handle this compound with care, as it can be corrosive and harmful if not properly handled.

InChI:InChI=1/C11H7ClOS/c12-11(13)10-7-6-9(14-10)8-4-2-1-3-5-8/h1-7H

Upstream product

• 19163-24-7 5-phenyl-2-thiophenecarboxylic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 19163-21-4 5-phenylthiophene-2-carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 13781-37-8 2-iodo-5-phenylthiophene 
• 69202-28-4 2-(3-Oxo-prop-1-enyl-1-phenyl-1-thio)-acetanilid 

Downstream Products

• 62404-17-5 N-(5-phenyl-2-thenoyl)piperidine 
• 62404-18-6 4-(5-phenyl-thiophene-2-carbonyl)-morpholine 
• 190076-85-8 5-Phenyl-thiophene-2-carboxylic acid tert-butylamide 
• 333792-84-0 N-[3-(2,3-dimethyl-3H-imidazol-4-yl)-phenyl]-5-phenyl-thiophene-2-carboxamide 
• 1025771-21-4 N-(2-chloro-5-((((1R)-1-phenylethyl)amino)methyl)-phenyl)-5-phenyl-2-thiophenecarboxamide 

Relevant articles and documents

Pine Rosin as a Valuable Natural Resource in the Synthesis of Fungicide Candidates for Controlling Fusarium oxysporum on Cucumber

To improve the effect of pine rosin in plant fungicides, four series of dehydroabietyl-1,3,4-thiadiazole derivatives from the natural product rosin were synthesized. Based on the evaluation of the in vitro antifungal activity against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium oxysporum, and Magnaporthe oryzae, rosin-based 1,3,4-thiadiazole compounds containing thiophene heterocycles were screened. Notably, compound 3e [dehydroabietyl-(1,3,4-thiadiazol-2-yl)-5-nitrothiophene-2-carboxamide] exhibited excellent antifungal property against F. oxysporum with an EC50 of 0.618 mg/L, which was lower than that of the positive control carbendazim (0.649 mg/L). The in vivo antifungal activity results showed that 3e exerted a protective effect on cucumber plants. Physiological and biochemical studies showed that the primary mechanism of action of compound 3e on F. oxysporum was it changed the mycelial morphology, increased the cell membrane permeability, and inhibited the synthesis of ergosterol in the mycelia. Furthermore, the quantitative structure-activity relationship studies revealed that the frontier orbital energy in the molecule had a key role in the antifungal activity through the conjugation and electrostatic interaction between compound 3e and the receptors of the target. Thus, the present study highlighted the application of rosin-based fungicidal candidates and exploited efficient plant pesticides for sustainable crop production.

Amide compounds

The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): wherein R1is a 4-(lower) alkyl-imidazol-1-yl or a 4,5-di(lower) alkyl-imidazol-1-yl group, R2is a hydrogen atom or a lower alkyl