1737-36-6 Usage
Description
4-CHLORO-3-(TRIFLUOROMETHYL)BENZOIC ACID is an off-white powder with chemical properties that make it a valuable compound in various applications. It is a derivative of benzoic acid, featuring a chloro group at the 4-position and a trifluoromethyl group at the 3-position, which imparts unique characteristics to the molecule.
Uses
Used in Pharmaceutical Industry:
4-CHLORO-3-(TRIFLUOROMETHYL)BENZOIC ACID is used as a key intermediate in the synthesis of pyrrolo[2,3-d]pyrimidine derivatives. These derivatives exhibit significant antiproliferative activity against melanoma cell lines, making them potential candidates for the development of novel therapeutic agents in oncology.
Used in Chemical Synthesis:
Due to its unique chemical structure, 4-CHLORO-3-(TRIFLUOROMETHYL)BENZOIC ACID can be utilized in various chemical synthesis processes. Its reactivity and functional groups allow it to be a building block for the creation of more complex organic compounds, which can be applied in different industries such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
4-CHLORO-3-(TRIFLUOROMETHYL)BENZOIC ACID serves as a valuable research tool for scientists working on the development of new drugs, materials, and chemical processes. Its unique properties and reactivity make it an interesting subject for study, potentially leading to new discoveries and innovations in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1737-36-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1737-36:
(6*1)+(5*7)+(4*3)+(3*7)+(2*3)+(1*6)=86
86 % 10 = 6
So 1737-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClF3O2/c9-6-2-1-4(7(13)14)3-5(6)8(10,11)12/h1-3H,(H,13,14)/p-1
1737-36-6Relevant articles and documents
Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent
Shi, Guangfa,Shao, Changdong,Pan, Shulei,Yu, Jingxun,Zhang, Yanghui
supporting information, p. 38 - 41 (2015/07/28)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).
Amine Compounds
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Page/Page column 164, (2008/12/08)
There is provided a compound exhibiting an activity of suppressing immune response with reduced adverse drug reactions, which compound is useful in the chemotherapy for preventing or treating, for example, a wide range of various autoimmune diseases including systemic erythematodes, chronic rheumatoid arthritis, Type I diabetes, inflammatory bowel disease, biliary cirrhosis, uveitis, multiple sclerosis or other disorders, or chronic inflammatory diseases, or cancers, lymphoma or leukemia, or resistance to organ or tissue transplantation or rejection against transplantation. Novel amine compounds having an S1P1/Edg1 receptor agonist effect, possible stereoisomers or racemic bodies of the compounds, or pharmacologically acceptable salts, hydrates or solvates of the compound, the stereoisomers or the racemic bodies, or prodrugs of the compounds, the stereoisomers, the racemic bodies, the salts, the hydrates or the solvates, are provided.
