173901-10-5Relevant articles and documents
Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.
Parmee,Naylor,Perkins,Colandrea,Ok,Candelore,Cascieri,Deng,Feeney,Forrest,Hom,MacIntyre,Miller,Stearns,Strader,Tota,Wyvratt,Fisher,Weber
, p. 749 - 754 (2007/10/03)
Human beta3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over beta1 and beta2 binding. L-760,087 (4a) and L-764,646 (5a) (beta3 EC50 = 18 and 14 nM, respectively) stimula
SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
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, (2008/06/13)
Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent