173901-20-7Relevant articles and documents
3-pyridylethanolamines: Potent and selective human β3 adrenergic receptor agonists
Naylor, Elizabeth M.,Colandrea, Vincent J.,Candelore, Mari R.,Cascieri, Margaret A.,Colwell Jr., Lawrence F.,Deng, Liping,Feeney, William P.,Forrest, Michael J.,Hom, Gary J.,MacIntyre, D. Euan,Strader, Catherine D.,Tota, Laurie,Wang, Pei-Ran,Wyvratt, Matthew J.,Fisher, Michael H.,Weber, Ann E.
, p. 3087 - 3092 (2007/10/03)
The 3-pyridylethanolamine L-757,793 is a potent β3 AR agonist (EC50 6.3 nM, 70% activation) with 1,300- and 500-fold selectivity over binding to the β1 and β2 ARs, respectively. L-757,793 stimulated lipolysis in rhesus monkeys (ED50 0.2 mg/kg) with a maximum response equivalent to that elicited by isoproterenol.