173934-26-4 Usage
Description
(R)-HOMOCITRIC ACID LACTONE is a chemical compound belonging to the family of carboxylic acids and derivatives. It is a lactone derivative of (R)-homocitric acid, which serves as an intermediate in the metabolism of lysine and tryptophan. (R)-HOMOCITRIC ACID LACTONE has demonstrated potential biological activities, such as inhibiting enzymes involved in the biosynthesis of lysine and tryptophan. Furthermore, it has been studied for its potential application in treating certain metabolic disorders and plays a role in the biosynthesis of specific natural products, making it a subject of interest for researchers in biochemistry and organic chemistry.
Uses
Used in Pharmaceutical Industry:
(R)-HOMOCITRIC ACID LACTONE is used as an inhibitor for enzymes involved in the biosynthesis of lysine and tryptophan, which can be beneficial for the development of treatments targeting metabolic disorders.
Used in Biochemical Research:
(R)-HOMOCITRIC ACID LACTONE is used as a research compound for studying the metabolic pathways of lysine and tryptophan, as well as the enzymes involved in their biosynthesis.
Used in Organic Chemistry:
(R)-HOMOCITRIC ACID LACTONE is used as a key intermediate in the synthesis of certain natural products, contributing to the advancement of organic chemistry and the development of novel compounds with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 173934-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,9,3 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 173934-26:
(8*1)+(7*7)+(6*3)+(5*9)+(4*3)+(3*4)+(2*2)+(1*6)=154
154 % 10 = 4
So 173934-26-4 is a valid CAS Registry Number.
173934-26-4Relevant articles and documents
Asymmetric Synthesis of Homocitric Acid Lactone
Nickerson, Leslie A.,Huynh, Valerie,Balmond, Edward I.,Cramer, Stephen P.,Shaw, Jared T.
, p. 11404 - 11408 (2016/11/28)
A short, diastereoselective synthesis of homocitric acid lactone is described. The key step is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only modest oxidation state manipulation to complete the synthesis. This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position.
An improved synthesis of trisodium (U)-homocitrate from citric acid
Prokop,Milewska
experimental part, p. 1317 - 1322 (2010/07/05)
A method of synthesis of trisodium (R)-homocitrate starting from citric acid is reported. The procedure affords the final product of high optical purity with satisfactory yield.
A facile method for synthesis of (R)-(-)- and (S)-(+)-homocitric acid lactones and related α-hydroxy dicarboxylic acids from D- or L-malic acid
Xu, Peng-Fei,Matsumoto, Tsuyoshi,Ohki, Yasuhiro,Tatsumi, Kazuyuki
, p. 3815 - 3818 (2007/10/03)
We report here a simple and convenient route for the stereoselective synthesis of (R)-(-)- and (S)-(+)-homocitric acid lactones, which play very important roles in biochemistry. The method involves only three steps, starting from the readily available met
