173963-91-2 Usage
Description
FMOC-CYS(3-(BOC-AMINO)-PROPYL)-OH, also known as Fmoc-Cys(Trt)-OH, is an unusual amino acid derivative characterized by its white powder form. It is a synthetic compound that serves as a lysine or arginine mimetic, which means it can be used as a substitute for these naturally occurring amino acids in various applications.
Uses
Used in Pharmaceutical Industry:
FMOC-CYS(3-(BOC-AMINO)-PROPYL)-OH is used as a lysine or arginine mimetic for the development of novel drug candidates. Its ability to mimic the properties of lysine and arginine allows researchers to create new molecules with potential therapeutic applications, particularly in the areas of protein engineering and drug design.
Used in Chemical Synthesis:
In the field of chemical synthesis, FMOC-CYS(3-(BOC-AMINO)-PROPYL)-OH is used as a building block for the synthesis of complex organic molecules, including peptides and other bioactive compounds. Its unique structure enables the creation of new molecules with specific properties and functions, which can be applied in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
FMOC-CYS(3-(BOC-AMINO)-PROPYL)-OH is also utilized in research and development for the study of protein structure, function, and interactions. Its role as a lysine or arginine mimetic allows scientists to investigate the effects of amino acid substitutions on protein stability, folding, and activity, providing valuable insights into the molecular mechanisms underlying various biological processes and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 173963-91-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,9,6 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 173963-91:
(8*1)+(7*7)+(6*3)+(5*9)+(4*6)+(3*3)+(2*9)+(1*1)=172
172 % 10 = 2
So 173963-91-2 is a valid CAS Registry Number.
173963-91-2Relevant articles and documents
Targeting multiple chorismate-utilizing enzymes with a single inhibitor: Validation of a three-stage design
Ziebart, Kristin T.,Dixon, Seth M.,Avila, Belem,El-Badri, Mohamed H.,Guggenheim, Kathryn G.,Kurth, Mark J.,Toney, Michael D.
scheme or table, p. 3718 - 3729 (2010/07/16)
Chorismate-utilizing enzymes are attractive antimicrobial drug targets due to their absence in humans and their central role in bacterial survival and virulence. The structural and mechanistic homology of a group of these inspired the goal of discovering inhibitors that target multiple enzymes. Previously, we discovered seven inhibitors of 4-amino-4-deoxychorismate synthase (ADCS) in an on-bead, fluorescent-based screen of a 2304-member one-bead-one-compound combinatorial library. The inhibitors comprise PAYLOAD and COMBI stages, which interact with active site and surface residues, respectively, and are linked by a SPACER stage. These seven compounds, and six derivatives thereof, also inhibit two other enzymes in this family, isochorismate synthase (IS) and anthranilate synthase (AS). The best binding compound inhibits ADCS, IS, and AS with K i values of 720, 56, and 80 μM, respectively. Inhibitors with varying SPACER lengths show the original choice of lysine to be optimal. Lastly, inhibition data confirm the PAYLOAD stage directs the inhibitors to the ADCS active site.
