173974-88-4

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE
• Synonyms: 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE;1-(4-bromophenyl)-2,2-difluoroethan-1-one
• CAS NO: 173974-88-4
• Molecular Formula: C₈H₅BrF₂O
• Molecular Weight: 235.0255064
• Mol File: 173974-88-4.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE(173974-88-4)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE(173974-88-4)

Safety Data

• Hazardous Substances Data: 173974-88-4(Hazardous Substances Data)

Usage

Description

1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE is a chemical compound characterized by its molecular formula C8H6BrF2O. It is a ketone that features a bromine atom, two fluorine atoms, and a phenyl group. This unique structure and reactivity make it a valuable compound in various fields, including organic synthesis, pharmaceutical research, and potentially, the development of new drugs and materials.

Uses

Used in Pharmaceutical Research:
1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE is used as a building block in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure allows for various chemical reactions and modifications, which can lead to the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE is used as a key intermediate for the synthesis of various complex organic compounds. Its reactivity and structural features make it a versatile component in the construction of a wide range of molecules.
Used in Agricultural and Chemical Industries:
1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE may also find applications in the agricultural and chemical industries as a precursor to other compounds. Its unique properties can be harnessed to produce a variety of products, contributing to the advancement of these industries.

Upstream product

• 173974-85-1 N-(1-4'-bromophenylethylidene)-n-butylamine 
• 413598-07-9 ((1-(4-bromophenyl)-2,2-difluorovinyl)oxy)trimethylsilane 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 454-31-9 ethyl difluoroacetate 
• 106-37-6 1.4-dibromobenzene 
• 67-56-1 methanol 
• 99-90-1 para-bromoacetophenone 
• 1337572-02-7 C₁₇H₁₉BrF₂O₂SSi 
• 586-75-4 4-chlorobenzoyl chloride 
• 18931-61-8 4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione 
• 589-87-7 1,4-bromoiodobenzene 
• 64929-35-7 3-(4-bromophenyl)-3-oxopropanoic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 887781-91-1 1-bromo-4-(3,3-difluoroprop-1-en-2-yl)benzene 
• 887781-90-0 2-(4-bromophenyl)-1,1-difluoropropan-2-ol 
• 887781-85-3 (S)-1-(4-bromophenyl)-2,2-difluoroethanol 
• 887781-84-2 (1R)-1-(4-bromophenyl)-2,2-difluoroethanol 
• 1022154-90-0 2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone 
• 1217864-27-1 C₈H₆⁽²⁾HBrF₂O 

Relevant articles and documents

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Direct Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions

A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones from widely available carboxylic acids is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chemicals. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.

Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions

CF2H groups are unique due to the combination of their lipophilic and hydrogen bonding properties. The strength of H-bonding is determined by the group to which it is appended. Several functional groups have been explored in this context includ