174180-87-1

Basic information

• Product Name: 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide
• Synonyms: 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide
• CAS NO: 174180-87-1
• Molecular Weight: 675.76
• Mol File: 174180-87-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide(174180-87-1)
• EPA Substance Registry System: 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide(174180-87-1)

Safety Data

• Hazardous Substances Data: 174180-87-1(Hazardous Substances Data)

Usage

Core Structure

Benzodiazepine

Substituents

1. Tert-butoxycarbonyl Group: Protecting group for amines, enhancing stability and controlling reactivity.
2. Indazole Moiety: A heterocyclic compound often found in pharmaceuticals, exhibiting diverse pharmacological activities.
3. Fluorophenyl Group: Commonly used in medicinal chemistry for enhancing pharmacokinetic properties and target binding.

Linker

Isopropyl acetamide, serving as a connecting bridge between the core structure and substituents.

Pharmaceutical Potential

The complex structure suggests potential pharmacological activities, making it valuable for drug development and research.

Further Investigation

Comprehensive analysis is necessary to fully elucidate its pharmacological profile, therapeutic potential, and safety profile for potential pharmaceutical applications.

Upstream product

• 174180-42-8 2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate 
• 174180-89-3 2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-(4-fluoro-phenyl)-N-isopropyl-acetamide 
• 174180-72-4 2-methyl-2-propanyl 3-methyl-1H-indazole-1-carboxylate 
• 174181-40-9 N-(2-nitrophenyl)-N-phenylmalonamic acid methyl ester 
• 194278-28-9 N-(2-aminophenyl)-N-phenylmalonamic acid methyl ester 
• 174180-88-2 2-bromo-N-(4-fluoro-phenyl)-N-isopropyl-acetamide 
• 70441-63-3 4-fluoro-N-isopropyl-aniline 
• 119-75-5 2-nitro-N-phenylaniline 
• 445-27-2 2'-Fluoroacetophenone 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

CCK or gastrin modulating benzo ?b!?1,4! diazepines derivatives

Benzo?b!?1,4!diazepine compounds of formula (I), where R1 is selected from C1 C6 alkyl, C3 -C6 cycloalkyl, phenyl, or substituted phenyl; R2 is selected from C3 -C6 alkyl, C3 C6 cycloalkyl, C3 -C6 alkenyl, benzyl, phenylC1 -C3 alkyl of substituted phenyl; or NR1 R2 together form 1,2,3,4-tetrahydroquinoline or benzazepine, mono-, di-, or trisubstituted independently with C1-6 alkyl C1-6 alkoxy or halogen substituents; p is an integer 0 or 1; q is an integer 0 or 1; r is an integer 0 or 1; t is an integer 0 or 1, provided that when r is 0 then t is 0; R3, R5, and R6 are independently hydrogen or C1-6 alkyl; R4 is C1-6 alkyl or C1-6 alkenyl; R7 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, phenyl, substituted phenyl, napthyl, heteroaryl, substituted heteroaryl, bicycloheteroaryl or substituted bicycloheteroaryl; or NR6 R7 together form a saturated 5,6, or 7 membered ring optionally interrupted by 1,2,3 or 4 N, S or O heteroatoms, with the proviso that any two O or S atoms are not bonded to each other, m is an integer selected from the group of 0, 1, 2, 3 or 4; R8 and R9 are selected from a variety of substituents; Z is hydrogen or halogen; novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).