17420-68-7 Usage
Description
4-(AZEPANE-1-SULFONYL)-BENZOIC ACID, also known as 4-[(Hexahydro-1H-azepin-1-yl)sulfonyl]benzoic Acid, is a chemical compound characterized by the presence of an azepane-1-sulfonyl group attached to a benzoic acid moiety. This unique structure endows it with potential applications in various fields, particularly in biological research and pharmaceutical development.
Uses
Used in Pharmaceutical Industry:
4-(AZEPANE-1-SULFONYL)-BENZOIC ACID is used as a pharmaceutical intermediate for the development of drugs targeting specific biological pathways. Its unique chemical structure allows it to interact with various biological targets, making it a promising candidate for the creation of new therapeutic agents.
Used in Biological Research:
4-(AZEPANE-1-SULFONYL)-BENZOIC ACID is used as a research tool in the study of lifespan-altering compounds for altering the lifespan of eukaryotic organisms. It aids in understanding the molecular mechanisms that regulate aging and longevity, potentially leading to the discovery of novel therapeutic approaches to extend healthy life spans.
Used in Drug Screening:
In the field of drug discovery, 4-(AZEPANE-1-SULFONYL)-BENZOIC ACID serves as a screening compound for identifying potential candidates that can modulate the lifespan of eukaryotic organisms. This screening process is crucial for the development of new drugs that can target aging-related diseases and promote overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 17420-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,2 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17420-68:
(7*1)+(6*7)+(5*4)+(4*2)+(3*0)+(2*6)+(1*8)=97
97 % 10 = 7
So 17420-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4S/c15-13(16)11-5-7-12(8-6-11)19(17,18)14-9-3-1-2-4-10-14/h5-8H,1-4,9-10H2,(H,15,16)/p-1
17420-68-7Relevant articles and documents
Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis
Batt, Sarah M.,Besra, Gurdyal S.,Fu, Lei,Huang, Haihong,Li, Gang,Lu, Yu,Qin, Rongfei,Wang, Bin,Wang, Pengxu,Wang, Yanan,Wu, Chengwei
, (2022/02/01)
A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.
